Preparation of Novel Dendrimeric Hyperbranched Polymer-GdO Composites Loaded With Sphingosine Inhibitor-I/II.
1/5 보강
Functionalized dendrimeric nanoparticles (BH40-PEG-F127-FA) were synthesized to develop a targeted delivery platform for combined therapeutic and imaging applications.
APA
Kutlu E, Emen FM, et al. (2026). Preparation of Novel Dendrimeric Hyperbranched Polymer-GdO Composites Loaded With Sphingosine Inhibitor-I/II.. Chemistry & biodiversity, 23(3), e02899. https://doi.org/10.1002/cbdv.202502899
MLA
Kutlu E, et al.. "Preparation of Novel Dendrimeric Hyperbranched Polymer-GdO Composites Loaded With Sphingosine Inhibitor-I/II.." Chemistry & biodiversity, vol. 23, no. 3, 2026, pp. e02899.
PMID
41872670 ↗
Abstract 한글 요약
Functionalized dendrimeric nanoparticles (BH40-PEG-F127-FA) were synthesized to develop a targeted delivery platform for combined therapeutic and imaging applications. Structural confirmation through FT-IR, H-NMR, C-NMR, and MALDI-TOF mass spectrometry verified the successful formation of the macromolecular architecture. The nanoparticles exhibited hydrodynamic sizes of 190-255 nm, while transmission electron microscopy revealed micellar structures ranging from 35 to 190 nm. The critical micelle concentration of the copolymer was determined as approximately 0.001 mg/mL. Thermal analyses demonstrated the stability of BH40-PEG and BH40-PEG-F127-FA. GdO and sphingosine kinase inhibitors (SKI-I/II) were incorporated using a supercritical CO method, and structural integrity after loading was confirmed by FT-IR and x-ray diffraction. Drug-release studies performed in phosphate-buffered saline (pH 6.7, 37°C) indicated a sustained release over 192 h. Cytotoxicity assays on A549 lung cancer cells and Beas-2B healthy epithelial cells revealed selective antiproliferative activity, while confocal microscopy demonstrated treatment-induced morphological alterations. Overall, BH40-PEG-F127-FA nanoparticles show strong potential as biocompatible carriers for targeted therapy and multimodal imaging.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Dendrimers
- Cell Proliferation
- Sphingosine
- Antineoplastic Agents
- Cell Survival
- Drug Liberation
- Nanoparticles
- Polymers
- Phosphotransferases (Alcohol Group Acceptor)
- Particle Size
- Molecular Structure
- Drug Carriers
- Polyethylene Glycols
- Drug Screening Assays
- Antitumor
- Boltorn H40
- dendrimeric polymers
- lung cancer
- sphingosine kinase inhibitors
- theranostic
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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