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Pulmonary complications with individualised vs. fixed positive end-expiratory pressure in older patients recovering from lung cancer surgery: a randomised trial.

무작위 임상시험 1/5 보강
Anaesthesia 2026
Retraction 확인
출처
PubMed DOI

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문
P · Population 대상 환자/모집단
400 patients were allocated randomly to individualised positive end-expiratory pressure (PEEP group) or a fixed positive end-expiratory pressure of 5 cmHO (PEEP group).
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
PEEP group 50/197 (25%), risk ratio 1.09, 95%CI 0.79-1.52, p = 0.60). [DISCUSSION] Electrical impedance tomography-guided individualised positive end-expiratory pressure reduced driving pressures and improved intra-operative oxygenation but did not decrease the incidence of postoperative pulmonary complications in older adults undergoing lung cancer surgery.

Wang W, Liu K, Huang C, Jiang Q, Ge Y, Sessler DI

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓
📝 환자 설명용 한 줄

[INTRODUCTION] Postoperative pulmonary complications are common after lung cancer surgery in older adults.

🔬 핵심 임상 통계 (초록에서 자동 추출 — 원문 검증 권장)
  • p-value p < 0.001
  • 95% CI 0.79-1.52

이 논문을 인용하기

↓ .bib ↓ .ris
APA Wang W, Liu K, et al. (2026). Pulmonary complications with individualised vs. fixed positive end-expiratory pressure in older patients recovering from lung cancer surgery: a randomised trial.. Anaesthesia. https://doi.org/10.1111/anae.70165
MLA Wang W, et al.. "Pulmonary complications with individualised vs. fixed positive end-expiratory pressure in older patients recovering from lung cancer surgery: a randomised trial.." Anaesthesia, 2026.
PMID 41815001 ↗
DOI 10.1111/anae.70165

Abstract

[INTRODUCTION] Postoperative pulmonary complications are common after lung cancer surgery in older adults. Individualised positive end-expiratory pressure may optimise intra-operative lung mechanics, but its effect on postoperative pulmonary complications is uncertain. We hypothesised that individualised positive end-expiratory pressure would reduce the incidence of postoperative pulmonary complications compared with a fixed positive end-expiratory pressure in older patients (age ≥ 60 years) undergoing lung cancer surgery.

[METHODS] In total, 400 patients were allocated randomly to individualised positive end-expiratory pressure (PEEP group) or a fixed positive end-expiratory pressure of 5 cmHO (PEEP group). The primary outcome was the incidence of postoperative pulmonary complications. Secondary outcomes included duration of postoperative hospital stay; extrapulmonary complications; 30-day postoperative complications; driving pressure; and oxygenation index.

[RESULTS] Median (IQR [range]) individualised positive end-expiratory pressure was 11 (9-11 [3-13]) cmHO during one-lung and 9 (7-9 [3-13]) cmHO during two-lung ventilation. Patients allocated to the PEEP group had lower driving pressures during one-lung (12 (11-14 [4-23]) vs. 15 (13-18 [7-24]) cmHO, p < 0.001) and two-lung ventilation (9 (7-13 [4-26]) vs. 12 (10-14 [5-26]) cmHO, p < 0.001) and a higher oxygenation index during one-lung ventilation (26.7 (20.3-34.4 [6.7-55.9]) vs. 22.7 (16.0-29.3 [8.8-58.9]) kPa, p < 0.001) compared with those allocated to the PEEP group. Despite this, the incidence of postoperative pulmonary complications was similar between groups (PEEP group 54/195 (28%) vs. PEEP group 50/197 (25%), risk ratio 1.09, 95%CI 0.79-1.52, p = 0.60).

[DISCUSSION] Electrical impedance tomography-guided individualised positive end-expiratory pressure reduced driving pressures and improved intra-operative oxygenation but did not decrease the incidence of postoperative pulmonary complications in older adults undergoing lung cancer surgery.

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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반