p53 mediated cell cytotoxicity and DNA damage in lung cancer cell line A549 triggered by a small peptide extracted from a probiotic strain Lacticaseibacillus casei.
1/5 보강
[BACKGROUND] Antimicrobial peptides are being explored as anticancer agents due to their selectivity toward transformed cells.
APA
Siddique JF, Kumari GRS, et al. (2026). p53 mediated cell cytotoxicity and DNA damage in lung cancer cell line A549 triggered by a small peptide extracted from a probiotic strain Lacticaseibacillus casei.. BMC biotechnology, 26(1). https://doi.org/10.1186/s12896-026-01119-z
MLA
Siddique JF, et al.. "p53 mediated cell cytotoxicity and DNA damage in lung cancer cell line A549 triggered by a small peptide extracted from a probiotic strain Lacticaseibacillus casei.." BMC biotechnology, vol. 26, no. 1, 2026.
PMID
41826945 ↗
Abstract 한글 요약
[BACKGROUND] Antimicrobial peptides are being explored as anticancer agents due to their selectivity toward transformed cells. We evaluated a small peptide from for anti-proliferative effects on A549 lung cancer cells and investigated apoptosis-related mechanisms in vitro.
[METHODS] Cell viability was assessed by MTT. Apoptosis-associated morphology was examined by AO/EB staining, DNA fragmentation by agarose gel electrophoresis, and gene expression by qRT-PCR (p53, BAX, BCL-2, CASP8, CASP7, CASP3).
[RESULTS] The peptide reduced A549 viability in a dose-dependent manner relative to L929 cells. AO/EB staining revealed early apoptotic nuclear morphology, and DNA fragmentation was observed. qRT-PCR showed , , , and .
[CONCLUSIONS] Data support apoptosis that is with . As per experimental evidence of the study, the peptide from has the potential to inhibit the proliferation of Lung cancer cell line A549.
[METHODS] Cell viability was assessed by MTT. Apoptosis-associated morphology was examined by AO/EB staining, DNA fragmentation by agarose gel electrophoresis, and gene expression by qRT-PCR (p53, BAX, BCL-2, CASP8, CASP7, CASP3).
[RESULTS] The peptide reduced A549 viability in a dose-dependent manner relative to L929 cells. AO/EB staining revealed early apoptotic nuclear morphology, and DNA fragmentation was observed. qRT-PCR showed , , , and .
[CONCLUSIONS] Data support apoptosis that is with . As per experimental evidence of the study, the peptide from has the potential to inhibit the proliferation of Lung cancer cell line A549.
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