Favorable Response to Chemotherapy with Durvalumab plus Tremelimumab in Two Cases of KRAS G12C-Positive Pulmonary Sarcomatoid Carcinoma: A Case Report.
증례보고
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
chemotherapy combined with durvalumab and tremelimumab (POSEIDON regimen)
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
They thereafter achieved excellent clinical outcomes, including complete and partial responses, with sustained benefits. The POSEIDON regimen may represent a potent therapeutic option for this rare patient population with multiple negative prognostic factors.
ℹ️ 이 논문은 무료 전문이 아직 없습니다. 코퍼스 전체의 43.7%는 무료 가능 (통계 →) · 🏥 기관 EZproxy로 시도
Pulmonary sarcomatoid carcinoma (PSC) and Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations are poor prognostic factors in non-small cell lung cancer.
APA
Ichikawa T, Kudo K, et al. (2026). Favorable Response to Chemotherapy with Durvalumab plus Tremelimumab in Two Cases of KRAS G12C-Positive Pulmonary Sarcomatoid Carcinoma: A Case Report.. Internal medicine (Tokyo, Japan). https://doi.org/10.2169/internalmedicine.6660-25
MLA
Ichikawa T, et al.. "Favorable Response to Chemotherapy with Durvalumab plus Tremelimumab in Two Cases of KRAS G12C-Positive Pulmonary Sarcomatoid Carcinoma: A Case Report.." Internal medicine (Tokyo, Japan), 2026.
PMID
41850829 ↗
Abstract 한글 요약
Pulmonary sarcomatoid carcinoma (PSC) and Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations are poor prognostic factors in non-small cell lung cancer. We report two cases of metastatic KRAS G12C-positive PSC in men (aged 69 and 66 years). Both patients were treated with chemotherapy combined with durvalumab and tremelimumab (POSEIDON regimen). They thereafter achieved excellent clinical outcomes, including complete and partial responses, with sustained benefits. The POSEIDON regimen may represent a potent therapeutic option for this rare patient population with multiple negative prognostic factors.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (4)
- Surgical Colonic Myeloid Sarcoma Following Bone Marrow Transplantation in a Patient With Acute Myeloid Leukemia With Myelodysplasia-Related Changes: A Case Report.
- Coexistence of monomorphic epitheliotropic intestinal T-cell lymphoma of the jejunum and bilateral adrenal pheochromocytomas: A case report.
- Clathrin-associated SCYL2 contributes to the activation of PI3K/AKT signaling and tumorigenesis through PTEN phosphorylation in adult T-cell leukemia/lymphoma.
- Selpercatinib-induced Acalculous Cholecystitis in an Elderly Patient with RET Fusion-positive Non-small Cell Lung Cancer: A Case Report.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- NG25 Enhances Anti-Tumor Immunity in -Mutant Colorectal Cancer.
- Association of immune-related adverse events with survival in patients receiving immune checkpoint inhibitor plus chemotherapy for lung cancer.
- DIP-like Adenocarcinoma Presenting as a Part-Solid Nodule: A Case Report.
- NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions.
- Dynamic fluorine-18 fluorodeoxyglucose PET for evaluating different-sized metastatic lymph nodes in patients with non-small cell lung cancers.
- Plain language summary of results from the DUO-E study: durvalumab given with or without olaparib in patients with advanced endometrial cancer.