Updated Review: Using the National Cancer Database for Outcomes-Based Research.
1/5 보강
[BACKGROUND] The National Cancer Database (NCDB) captures 73.7% of newly diagnosed cancers in the United States and underpins thousands of outcomes studies informing oncologic practice.
APA
Ayoade OF, Caturegli G, et al. (2026). Updated Review: Using the National Cancer Database for Outcomes-Based Research.. Journal of the American College of Surgeons. https://doi.org/10.1097/XCS.0000000000001924
MLA
Ayoade OF, et al.. "Updated Review: Using the National Cancer Database for Outcomes-Based Research.." Journal of the American College of Surgeons, 2026.
PMID
41848188 ↗
Abstract 한글 요약
[BACKGROUND] The National Cancer Database (NCDB) captures 73.7% of newly diagnosed cancers in the United States and underpins thousands of outcomes studies informing oncologic practice. To remain relevant amid rapid therapeutic and policy changes, the NCDB has undergone substantial structural and variable-level revisions. We characterized major updates over the past decade and their implications for research.
[STUDY DESIGN] We performed a narrative review of annual NCDB data dictionary revisions, American College of Surgeons bulletins, and internal program updates in collaboration with NCDB leadership. Structural modifications, variable additions, and policy changes affecting data capture, follow-up, staging, and accessibility were systematically summarized.
[RESULTS] The NCDB now includes data from 1,413 Commission on Cancer-accredited hospitals and more than 55 million records. Since 2020, the Rapid Cancer Reporting System enables near-real-time monthly submissions. Embargo periods were reduced from 5 years to 3 years for survival data and 2 years for other variables, increasing analytic timeliness. Follow-up was limited to 15 years beginning January 1, 2022. Variable refinements include continuous tumor size in millimeters (since 2016), separation of tumor grade into clinical, pathologic, and post-therapy fields (since 2018), phased radiation treatment reporting (since 2018), and AJCC 8 th edition staging implementation in January 2018 with 9 th edition rollout ongoing. New data elements include Medicaid expansion status (2020), COVID-19 variables (2020-2021; 12.4% reduction in cases in 2020), smoking status (2023), and planned PD-L1 reporting for non-small cell lung cancer beginning in 2025.
[CONCLUSIONS] The NCDB has evolved toward more granular, contemporary, and policy-relevant data capture while maintaining broad national coverage. Investigators must account for staging transitions, variable maturation, follow-up limits, and registry-specific biases to ensure valid interpretation of NCDB-based research.
[STUDY DESIGN] We performed a narrative review of annual NCDB data dictionary revisions, American College of Surgeons bulletins, and internal program updates in collaboration with NCDB leadership. Structural modifications, variable additions, and policy changes affecting data capture, follow-up, staging, and accessibility were systematically summarized.
[RESULTS] The NCDB now includes data from 1,413 Commission on Cancer-accredited hospitals and more than 55 million records. Since 2020, the Rapid Cancer Reporting System enables near-real-time monthly submissions. Embargo periods were reduced from 5 years to 3 years for survival data and 2 years for other variables, increasing analytic timeliness. Follow-up was limited to 15 years beginning January 1, 2022. Variable refinements include continuous tumor size in millimeters (since 2016), separation of tumor grade into clinical, pathologic, and post-therapy fields (since 2018), phased radiation treatment reporting (since 2018), and AJCC 8 th edition staging implementation in January 2018 with 9 th edition rollout ongoing. New data elements include Medicaid expansion status (2020), COVID-19 variables (2020-2021; 12.4% reduction in cases in 2020), smoking status (2023), and planned PD-L1 reporting for non-small cell lung cancer beginning in 2025.
[CONCLUSIONS] The NCDB has evolved toward more granular, contemporary, and policy-relevant data capture while maintaining broad national coverage. Investigators must account for staging transitions, variable maturation, follow-up limits, and registry-specific biases to ensure valid interpretation of NCDB-based research.