FOXM1-specific TCR-engineered T cells target non-small cell lung cancer.
1/5 보강
FOXM1 is highly expressed in various cancer types and considered a key driver of cancer progression.
APA
Bontekoe E, Zhang M, et al. (2026). FOXM1-specific TCR-engineered T cells target non-small cell lung cancer.. Cancer immunology research. https://doi.org/10.1158/2326-6066.CIR-25-0605
MLA
Bontekoe E, et al.. "FOXM1-specific TCR-engineered T cells target non-small cell lung cancer.." Cancer immunology research, 2026.
PMID
41854516 ↗
Abstract 한글 요약
FOXM1 is highly expressed in various cancer types and considered a key driver of cancer progression. Accordingly, we evaluated the immunogenicity of FOXM1 and investigated the feasibility of targeting this transcription factor using T cell receptor (TCR) engineering. We identified epitopes derived from FOXM1 which were immunogenic on HLA-A*02:01, HLA-A*24:02, and HLA-A*23:01, endogenously-processed and presented, and resulted in T cell activation and cytotoxic T cell responses. Following the generation of TCR-T cells, sensitivity and specificity were confirmed by peptide dose-response and X-scan, respectively. Most importantly, adoptive transfer of TCR engineered T cells led to a significant reduction in tumor growth, as well as significantly prolonged survival in a tumor-bearing immunocompromised murine model. Our studies confirm the immunogenicity of FOXM1 and feasibility of targeting this antigen using TCR-engineering.