New Onset Heart Failure Induced by Glumetinib: A Case Report.
[PURPOSE] We present the first case report of new-onset heart failure associated with glumetinib.
APA
Li X, Zhang W, et al. (2026). New Onset Heart Failure Induced by Glumetinib: A Case Report.. Clinical therapeutics, 48(4), 385-388. https://doi.org/10.1016/j.clinthera.2026.02.009
MLA
Li X, et al.. "New Onset Heart Failure Induced by Glumetinib: A Case Report.." Clinical therapeutics, vol. 48, no. 4, 2026, pp. 385-388.
PMID
41864774
Abstract
[PURPOSE] We present the first case report of new-onset heart failure associated with glumetinib.
[METHODS] The Naranjo Adverse Drug Reaction Probability Scale was used to assess causality.
[FINDINGS] The Naranjo scale generated a score of 7, suggesting a probable association between heart failure and glumetinib therapy. This may result from HGF/MET pathway inhibition, compromising cardiomyocyte self-protection and causing direct cardiac toxicity.
[IMPLICATIONS] A probable association exists between heart failure and glumetinib.
[METHODS] The Naranjo Adverse Drug Reaction Probability Scale was used to assess causality.
[FINDINGS] The Naranjo scale generated a score of 7, suggesting a probable association between heart failure and glumetinib therapy. This may result from HGF/MET pathway inhibition, compromising cardiomyocyte self-protection and causing direct cardiac toxicity.
[IMPLICATIONS] A probable association exists between heart failure and glumetinib.
MeSH Terms
Humans; Heart Failure; Male; Protein Kinase Inhibitors; Female; Pyrazoles; Pyridines
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