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Population Pharmacokinetics of Serplulimab and Quantitative Assessment of Transitioning From Weight-Based to Flat-Dosing Strategy.

2/5 보강

CPT: pharmacometrics & systems pharmacology 📖 저널 OA 96.2% 2024~2026 2026 Vol.15(4) p. e70204 OA Lung Cancer Research Studies

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

2110 patients were analyzed using nonlinear mixed-effects modeling.

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

Exposure-response (E-R) analyses revealed no meaningful association between exposure and outcomes. The PopPK model adequately described serplulimab PK and supports transitioning from WT-based to flat-dosing, demonstrating comparable exposure, efficacy, and safety across regimens.

OpenAlex 토픽 · Lung Cancer Research Studies Monoclonal and Polyclonal Antibodies Research Lung Cancer Treatments and Mutations

Wang K, Shen Y, Hu C, Xu F, Kwok Z, Wang Q

📖 무료 전문 🔓 OA PDF oa

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