Secondary Metabolites of Ainsliaea fragrans and Their Cytotoxic Activity.
2/5 보강
OpenAlex 토픽 ·
Sesquiterpenes and Asteraceae Studies
Plant chemical constituents analysis
Essential Oils and Antimicrobial Activity
Phytochemical investigation of Ainsliaea fragrans led to the isolation of two new compounds, a coumarin derivative ainslfragrsin A (1) and a sesquiterpenoid ainslfragrsin B (2), along with seven known
APA
Mengfei Wang, Wei‐Cheng He, et al. (2026). Secondary Metabolites of Ainsliaea fragrans and Their Cytotoxic Activity.. Chemistry & biodiversity, 23(4), e03421. https://doi.org/10.1002/cbdv.202503421
MLA
Mengfei Wang, et al.. "Secondary Metabolites of Ainsliaea fragrans and Their Cytotoxic Activity.." Chemistry & biodiversity, vol. 23, no. 4, 2026, pp. e03421.
PMID
41983304 ↗
Abstract 한글 요약
Phytochemical investigation of Ainsliaea fragrans led to the isolation of two new compounds, a coumarin derivative ainslfragrsin A (1) and a sesquiterpenoid ainslfragrsin B (2), along with seven known compounds (3-9). Their structures were elucidated by comprehensive spectroscopic analyses (MS, IR, UV, and NMR) and comparison with data reported in the literature. The absolute configurations of compounds 1-2 were assigned by comparing the experimental and calculated electronic circular dichroism (ECD) spectra. Structurally, compound 1 was a rare coumarin derivative, featuring a phenylethane unit connected to the coumarin scaffold via a C─C bridge at C-8. All the isolated compounds exhibited cytotoxic activities against the human lung cancer cell line A549 in the MTT assay, and compounds 1-2 and 4-6 exhibited moderate inhibitory activity with IC values ranging from 38.7 to 65.1 µM.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Antineoplastic Agents
- Phytogenic
- Drug Screening Assays
- Antitumor
- Coumarins
- Asteraceae
- Molecular Structure
- Cell Proliferation
- Structure-Activity Relationship
- Cell Line
- Tumor
- Dose-Response Relationship
- Drug
- Sesquiterpenes
- A549 Cells
- Secondary Metabolism
- Cell Survival
- Molecular Conformation
- Ainsliaea fragrans
- Cytotoxic activities
- Lung cancer
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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