Pleomorphic Carcinoma With EGFR and Concomitant Mutations Transformed From Lung Adenocarcinoma: A Case Report.
[BACKGROUND] Transformation to small cell carcinoma, squamous cell carcinoma, and rarely, pleomorphic carcinoma (PC) has been reported to be found in EGFR-mutated lung cancer with acquired resistance
APA
Akazawa Y, Sato T, et al. (2026). Pleomorphic Carcinoma With EGFR and Concomitant Mutations Transformed From Lung Adenocarcinoma: A Case Report.. Cancer reports (Hoboken, N.J.), 9(4), e70546. https://doi.org/10.1002/cnr2.70546
MLA
Akazawa Y, et al.. "Pleomorphic Carcinoma With EGFR and Concomitant Mutations Transformed From Lung Adenocarcinoma: A Case Report.." Cancer reports (Hoboken, N.J.), vol. 9, no. 4, 2026, pp. e70546.
PMID
42002533
Abstract
[BACKGROUND] Transformation to small cell carcinoma, squamous cell carcinoma, and rarely, pleomorphic carcinoma (PC) has been reported to be found in EGFR-mutated lung cancer with acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). However, evidence for underlying factors including genomic profiles associated with PC transformation has been lacking.
[CASE] We report a case of EGFR-mutated lung adenocarcinoma that transformed to PC confirmed by an autopsy after stereotactic radiotherapy and treatment with EGFR-TKIs. Comprehensive genomic profiling of the autopsy tissue revealed BRAF G466A, KRAS L19F, and NF1 Q2324* mutations in addition to EGFR E746_A750del. Anti-cancer treatments with radiation and EGFR-TKIs accompanying these gene alterations might induce the histological transformation and resistance to EGFR-TKIs.
[CONCLUSION] This report adds an insight into the involvement of genetic events in histological transformation in EGFR-mutated lung cancer.
[CASE] We report a case of EGFR-mutated lung adenocarcinoma that transformed to PC confirmed by an autopsy after stereotactic radiotherapy and treatment with EGFR-TKIs. Comprehensive genomic profiling of the autopsy tissue revealed BRAF G466A, KRAS L19F, and NF1 Q2324* mutations in addition to EGFR E746_A750del. Anti-cancer treatments with radiation and EGFR-TKIs accompanying these gene alterations might induce the histological transformation and resistance to EGFR-TKIs.
[CONCLUSION] This report adds an insight into the involvement of genetic events in histological transformation in EGFR-mutated lung cancer.
MeSH Terms
Humans; ErbB Receptors; Adenocarcinoma of Lung; Mutation; Lung Neoplasms; Male; Protein Kinase Inhibitors; Cell Transformation, Neoplastic; Proto-Oncogene Proteins p21(ras); Aged; Adenocarcinoma; Middle Aged; Fatal Outcome; Drug Resistance, Neoplasm; Proto-Oncogene Proteins B-raf; Neurofibromin 1
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