Pulmonary artery enlargement predicts mortality on low-dose lung cancer screening CT.
2/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
777 patients undergoing low-dose screening CT's at a tertiary academic center (2014-2018) were retrospectively identified.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
On multivariate analysis, PA dilation remained independently associated with increased mortality (HR = 1.83; 95% CI: 1.20-2.79; P = 0.005), along with age, underweight BMI, smoking status, hypertension, and higher Goddard scores. [CONCLUSION] PA enlargement on low-dose CT independently predicts worse survival and may help risk-stratify asymptomatic patients undergoing lung cancer screening.
OpenAlex 토픽 ·
Lung Cancer Diagnosis and Treatment
Cardiac Imaging and Diagnostics
Radiomics and Machine Learning in Medical Imaging
[BACKGROUND] Although pulmonary artery (PA) enlargement on computed tomography (CT) has been linked to adverse cardiopulmonary outcomes, its prognostic significance in asymptomatic individuals undergo
- p-value P < 0.05
- p-value P = 0.005
- 95% CI 1.20-2.79
- HR 1.83
APA
Shervin Zoghi, Mehrad Rokni, et al. (2026). Pulmonary artery enlargement predicts mortality on low-dose lung cancer screening CT.. Clinical imaging, 134, 110806. https://doi.org/10.1016/j.clinimag.2026.110806
MLA
Shervin Zoghi, et al.. "Pulmonary artery enlargement predicts mortality on low-dose lung cancer screening CT.." Clinical imaging, vol. 134, 2026, pp. 110806.
PMID
41990692
Abstract
[BACKGROUND] Although pulmonary artery (PA) enlargement on computed tomography (CT) has been linked to adverse cardiopulmonary outcomes, its prognostic significance in asymptomatic individuals undergoing low-dose lung cancer screening CT's remains unclear.
[PURPOSE] To evaluate the prognostic value of PA enlargement for predicting mortality in asymptomatic patients undergoing low-dose CT lung cancer screenings.
[MATERIALS AND METHODS] A total of 777 patients undergoing low-dose screening CT's at a tertiary academic center (2014-2018) were retrospectively identified. PA diameter and PA:AA ratio were measured. The primary endpoint was overall survival (OS), calculated from the date of reference CT to death or censoring at last follow-up. For survival analysis, patients with ≥3 years follow-up were included. Clinical and imaging variables were analyzed using univariate Cox proportional hazard model and statistically significant variables (P < 0.05) were entered into multivariable analysis to identify independent predictors of mortality. All statistical analyses were performed using Python (pandas, seaborn, lifelines).
[RESULTS] Sex-specific PA diameter thresholds (90th percentile: 29 mm men, 27 mm women) were applied. PA dilation was present in 179 patients (23%). On univariate analysis, age, underweight BMI, smoking status, diabetes, hypertension, coronary artery disease, PA dilation (absolute and PA:AA ratio), and emphysema severity (Goddard score) were associated with decreased survival. On multivariate analysis, PA dilation remained independently associated with increased mortality (HR = 1.83; 95% CI: 1.20-2.79; P = 0.005), along with age, underweight BMI, smoking status, hypertension, and higher Goddard scores.
[CONCLUSION] PA enlargement on low-dose CT independently predicts worse survival and may help risk-stratify asymptomatic patients undergoing lung cancer screening.
[PURPOSE] To evaluate the prognostic value of PA enlargement for predicting mortality in asymptomatic patients undergoing low-dose CT lung cancer screenings.
[MATERIALS AND METHODS] A total of 777 patients undergoing low-dose screening CT's at a tertiary academic center (2014-2018) were retrospectively identified. PA diameter and PA:AA ratio were measured. The primary endpoint was overall survival (OS), calculated from the date of reference CT to death or censoring at last follow-up. For survival analysis, patients with ≥3 years follow-up were included. Clinical and imaging variables were analyzed using univariate Cox proportional hazard model and statistically significant variables (P < 0.05) were entered into multivariable analysis to identify independent predictors of mortality. All statistical analyses were performed using Python (pandas, seaborn, lifelines).
[RESULTS] Sex-specific PA diameter thresholds (90th percentile: 29 mm men, 27 mm women) were applied. PA dilation was present in 179 patients (23%). On univariate analysis, age, underweight BMI, smoking status, diabetes, hypertension, coronary artery disease, PA dilation (absolute and PA:AA ratio), and emphysema severity (Goddard score) were associated with decreased survival. On multivariate analysis, PA dilation remained independently associated with increased mortality (HR = 1.83; 95% CI: 1.20-2.79; P = 0.005), along with age, underweight BMI, smoking status, hypertension, and higher Goddard scores.
[CONCLUSION] PA enlargement on low-dose CT independently predicts worse survival and may help risk-stratify asymptomatic patients undergoing lung cancer screening.