Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature.
2/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
68 patients, we accurately differentiate between benign lung changes and early-stage lung cancer.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
These findings underscore the potential of sEVs as diagnostic markers for cancer screening. Furthermore, the multiplex microfluidic device's scalability, simplicity, and cost-effectiveness indicate feasibility for large-scale population screening.
OpenAlex 토픽 ·
Extracellular vesicles in disease
Phagocytosis and Immune Regulation
S100 Proteins and Annexins
Small extracellular vesicles (sEVs) offer a promising, non-invasive method for cancer detection.
APA
Richard J. Lobb, Quan Zhou, et al. (2026). Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature.. Cell reports. Medicine, 7(4), 102694. https://doi.org/10.1016/j.xcrm.2026.102694
MLA
Richard J. Lobb, et al.. "Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature.." Cell reports. Medicine, vol. 7, no. 4, 2026, pp. 102694.
PMID
41881025 ↗
Abstract 한글 요약
Small extracellular vesicles (sEVs) offer a promising, non-invasive method for cancer detection. Despite global research efforts, successful translation of sEV-based diagnostics remains limited. In this study, we identify a 4-protein sEV biomarker panel (thrombospondin-1, nidogen-1, pentraxin-3, and versican) based on proteomic profiles obtained from an isogenic cancer cell line model. The panel's performance is validated across 22 cancer cell lines and 764 retrospective plasma/serum samples spanning multiple cancer types, yielding robust performance (area under the curve [AUC]: 0.91-1.00). To facilitate clinical application, we develop a multiplex sEV device that integrates nanoshearing-based microfluidics and surface-enhanced Raman scattering (SERS) for simultaneous detection of the 4-protein panel. Using this device on a prospective cohort of 68 patients, we accurately differentiate between benign lung changes and early-stage lung cancer. These findings underscore the potential of sEVs as diagnostic markers for cancer screening. Furthermore, the multiplex microfluidic device's scalability, simplicity, and cost-effectiveness indicate feasibility for large-scale population screening.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Extracellular Vesicles
- Biomarkers
- Tumor
- Early Detection of Cancer
- Cell Line
- Female
- Neoplasms
- Male
- Lung Neoplasms
- Proteomics
- Middle Aged
- Prospective Studies
- Serum Amyloid P-Component
- extracellular vesicles
- liquid biopsy
- lung cancer screening
- microfluidics
- miniaturized biosensor
- multi-cancer early diagnosis
- surface-enhanced Raman spectroscopy
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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