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Preoperative brain natriuretic peptide levels are associated with postoperative all-cause mortality in patients with lung cancer.

2/5 보강
Surgery today 📖 저널 OA 10.4% 2026 Vol.56(5) p. 707-720 Cardiac, Anesthesia and Surgical Out
TL;DR Preoperative BNP levels in patients with lung cancer may indicate a potentially compromised condition and can be associated with the postoperative OS, however, the link between the BNP level and lung cancer severity remains unclear.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-04-29

PICO 자동 추출 (휴리스틱, conf 3/4)

유사 논문
P · Population 대상 환자/모집단
환자: lung cancer may indicate a potentially compromised condition and can be associated with the postoperative OS
I · Intervention 중재 / 시술
radical resection for lung cancer at our institution between January 2012 and June 2019 were divided into the high- (≥ 18
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] Preoperative BNP levels in patients with lung cancer may indicate a potentially compromised condition and can be associated with the postoperative OS. However, the link between the BNP level and lung cancer severity remains unclear.
OpenAlex 토픽 · Cardiac, Anesthesia and Surgical Outcomes Heart Failure Treatment and Management Cancer, Stress, Anesthesia, and Immune Response

Otsuka S, Shiiya H, Takagi R, Okada K, Sasaki A, Ohtaka K, Fujiwara-Kuroda A, Ujiie H, Aragaki M, Kato T

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Preoperative BNP levels in patients with lung cancer may indicate a potentially compromised condition and can be associated with the postoperative OS, however, the link between the BNP level and lung

🔬 핵심 임상 통계 (초록에서 자동 추출 — 원문 검증 권장)
  • p-value p = 0.03
  • p-value p = 0.09

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↓ .bib ↓ .ris
APA Shinya Otsuka, Haruhiko Shiiya, et al. (2026). Preoperative brain natriuretic peptide levels are associated with postoperative all-cause mortality in patients with lung cancer.. Surgery today, 56(5), 707-720. https://doi.org/10.1007/s00595-025-03108-9
MLA Shinya Otsuka, et al.. "Preoperative brain natriuretic peptide levels are associated with postoperative all-cause mortality in patients with lung cancer.." Surgery today, vol. 56, no. 5, 2026, pp. 707-720.
PMID 41247465 ↗
DOI 10.1007/s00595-025-03108-9

Abstract

[PURPOSE] Serum levels of cardiovascular markers, including brain natriuretic peptide (BNP), are associated with the prognosis of cancer patients. This study examined the relationship between the preoperative blood BNP level and the long-term prognosis after curative lung cancer resection.

[METHODS] Patients who underwent radical resection for lung cancer at our institution between January 2012 and June 2019 were divided into the high- (≥ 18.5 pg/ml) and low- (< 18.5 pg/ml) BNP groups. Kaplan-Meier curves were used to analyze the postoperative overall survival (OS) and relapse-free survival (RFS). The cumulative incidence function (CIF) was analyzed using the Gray's test. Univariate and multivariate Cox proportional hazards models were used to identify independent predictors of the OS.

[RESULTS] The postoperative OS was significantly worse in the high-BNP group than in the low-BNP group (p = 0.03), but there was no statistically significant difference in the RFS (p = 0.09). A CIF analysis indicated that non-cancer-related deaths had a greater impact on the RFS than cancer recurrence. Blood BNP levels possibly affected the OS independently (hazard ratio, 1.50).

[CONCLUSIONS] Preoperative BNP levels in patients with lung cancer may indicate a potentially compromised condition and can be associated with the postoperative OS. However, the link between the BNP level and lung cancer severity remains unclear.

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