Symptom Cluster Trajectories of Cough, Shortness of Breath, and Disturbed Sleep in Patients Undergoing Lung Cancer Surgery: A Longitudinal Study.
TL;DR
There is significant heterogeneity in the trajectories of the cough, shortness of breath, and disturbed sleep symptom cluster, and early identification of high-risk groups may facilitate targeted interventions to improve outcomes.
OpenAlex 토픽 ·
Cancer survivorship and care
Chronic Obstructive Pulmonary Disease (COPD) Research
Lung Cancer Diagnosis and Treatment
There is significant heterogeneity in the trajectories of the cough, shortness of breath, and disturbed sleep symptom cluster, and early identification of high-risk groups may facilitate targeted inte
- 표본수 (n) 814
- p-value P = 0.01
- p-value P = 0.02
- 95% CI 0.41-0.87
- OR 0.59
- 연구 설계 cohort study
APA
Heling Zhou, Junlin Lei, et al. (2026). Symptom Cluster Trajectories of Cough, Shortness of Breath, and Disturbed Sleep in Patients Undergoing Lung Cancer Surgery: A Longitudinal Study.. Annals of surgical oncology, 33(5), 4194-4203. https://doi.org/10.1245/s10434-025-18994-z
MLA
Heling Zhou, et al.. "Symptom Cluster Trajectories of Cough, Shortness of Breath, and Disturbed Sleep in Patients Undergoing Lung Cancer Surgery: A Longitudinal Study.." Annals of surgical oncology, vol. 33, no. 5, 2026, pp. 4194-4203.
PMID
41495501
Abstract
[BACKGROUND] The symptom cluster of cough, shortness of breath, and disturbed sleep is common in patients undergoing lung cancer surgery, but its longitudinal patterns remain unclear. This study aimed to identify distinct cluster trajectories and associated factors.
[METHODS] Data were drawn from a cohort study on perioperative patient-reported outcomes of lung cancer patients. Symptoms were measured with the Perioperative Symptom Assessment for Lung Surgery (PSA-Lung) at eight time points: preoperation, postoperative day 1, at discharge, and 1, 3, 6, 9, and 12 months postdischarge. A parallel-process latent growth curve model identified trajectory classes, and multivariate logistic regression explored associated factors.
[RESULTS] Among 1377 patients, three trajectory classes were identified: persistently low (N = 814, 60.8%), persistently declining (N = 410, 30.7%), and persistently moderate (N = 114, 8.5%). Male sex (OR = 0.59, 95% CI 0.41-0.87, P = 0.01), no readmission (OR = 0.42, 95% CI 0.20-0.89, P = 0.02), were associated with the "persistently low" trajectory. Lower education level of middle school and below (OR = 2.05, 95% CI 1.07-3.92, P = 0.03), annual family income <100,000 CNY (OR = 2.00, 95% CI 1.01-3.97, P = 0.048), lymph node sampling (OR = 0.41, 95% CI 0.17-0.99, P = 0.047), and high hospitalization costs (OR = 1.37, 95% CI 1.14-1.65, P = 0.001) were associated with the "persistently moderate" trajectory.
[CONCLUSIONS] There is significant heterogeneity in the trajectories of the cough, shortness of breath, and disturbed sleep symptom cluster. Early identification of high-risk groups may facilitate targeted interventions to improve outcomes.
[METHODS] Data were drawn from a cohort study on perioperative patient-reported outcomes of lung cancer patients. Symptoms were measured with the Perioperative Symptom Assessment for Lung Surgery (PSA-Lung) at eight time points: preoperation, postoperative day 1, at discharge, and 1, 3, 6, 9, and 12 months postdischarge. A parallel-process latent growth curve model identified trajectory classes, and multivariate logistic regression explored associated factors.
[RESULTS] Among 1377 patients, three trajectory classes were identified: persistently low (N = 814, 60.8%), persistently declining (N = 410, 30.7%), and persistently moderate (N = 114, 8.5%). Male sex (OR = 0.59, 95% CI 0.41-0.87, P = 0.01), no readmission (OR = 0.42, 95% CI 0.20-0.89, P = 0.02), were associated with the "persistently low" trajectory. Lower education level of middle school and below (OR = 2.05, 95% CI 1.07-3.92, P = 0.03), annual family income <100,000 CNY (OR = 2.00, 95% CI 1.01-3.97, P = 0.048), lymph node sampling (OR = 0.41, 95% CI 0.17-0.99, P = 0.047), and high hospitalization costs (OR = 1.37, 95% CI 1.14-1.65, P = 0.001) were associated with the "persistently moderate" trajectory.
[CONCLUSIONS] There is significant heterogeneity in the trajectories of the cough, shortness of breath, and disturbed sleep symptom cluster. Early identification of high-risk groups may facilitate targeted interventions to improve outcomes.
MeSH Terms
Humans; Male; Female; Lung Neoplasms; Cough; Dyspnea; Sleep Wake Disorders; Middle Aged; Longitudinal Studies; Aged; Follow-Up Studies; Prognosis; Pneumonectomy; Postoperative Complications
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