Volume and location of screen-detected lung nodules associated with lung cancer within two-year follow-up: Post hoc analysis from the UK Lung Cancer Screening (UKLS) trial.
2/5 보강
TL;DR
Solid and part-solid nodules with volume ≥300 mm3 were more often found in the upper lobes and were associated with a higher probability of lung cancer within a two-year follow-up period.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
57 participants with 62 nonsolid nodules ≥8 mm were included.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The 2-year lung cancer probability was higher in nodules ≥300 mm (RR 18.1, 95% CI 5.6-58.4; p < 0.001) and in upper lobe nodules (RR 2.7, 95% CI 1.3-5.5; p = 0.009). [CONCLUSION] Solid and part-solid nodules with volume ≥300 mm were more often found in the upper lobes and were associated with a higher probability of lung cancer within a two-year follow-up period.
OpenAlex 토픽 ·
Lung Cancer Diagnosis and Treatment
Lung Cancer Treatments and Mutations
Lung Cancer Research Studies
Solid and part-solid nodules with volume ≥300 mm3 were more often found in the upper lobes and were associated with a higher probability of lung cancer within a two-year follow-up period.
- p-value p < 0.001
- p-value p = 0.009
- 95% CI 1.12-3.48
APA
Oke Dimas Asmara, Harriet L. Lancaster, et al. (2026). Volume and location of screen-detected lung nodules associated with lung cancer within two-year follow-up: Post hoc analysis from the UK Lung Cancer Screening (UKLS) trial.. Lung cancer (Amsterdam, Netherlands), 215, 109352. https://doi.org/10.1016/j.lungcan.2026.109352
MLA
Oke Dimas Asmara, et al.. "Volume and location of screen-detected lung nodules associated with lung cancer within two-year follow-up: Post hoc analysis from the UK Lung Cancer Screening (UKLS) trial.." Lung cancer (Amsterdam, Netherlands), vol. 215, 2026, pp. 109352.
PMID
41806497
Abstract
[INTRODUCTION] Follow-up of radiologically suspicious lung nodules from screening programs remains complex and unstandardized. This study analyses distribution and characteristics of solid and part-solid non-calcified nodules ≥100 mm and non-solid nodules ≥8 mm detected at baseline in the UK Lung cancer Screening (UKLS) trial, with insights into their relationship to screen-detected lung cancers.
[METHODS] UKLS participants with baseline indeterminate and positive lung nodules were included. Nodule location was categorized by lobe and by attachment: intraparenchymal, juxta pleural or pleural-based. Solid and part-solid were classified based on semi-automated volume: 100-300 mm and ≥300 mm, and non-solid nodules based on diameter ≥8 mm. This measurement approach aligns with UKLS protocol and the British Thoracic Society (BTS) guideline. Their relationship to screen-detected lung cancer was based on histological outcomes after a 2-year follow-up period.
[RESULTS] 279 UKLS participants with 373 solid or part-solid lung nodules ≥100 mm and 57 participants with 62 nonsolid nodules ≥8 mm were included. Among solid and part-solid nodules, 233 were 100-300 mm, with 39.5% in upper lobes and 72.5% intraparenchymal; 140 nodules were ≥300 mm, with 51.4% in upper lobes and 53.6% intraparenchymal. Nodules ≥300 mm group were more likely to be in the upper lobes (OR 1.97 [95% CI 1.12-3.48]). Within 2 years, 34 solid or part-solid nodules were diagnosed as lung cancer, yielding a 2-year cancer probability of 9.1% (95% CI 6.6-12.5). The 2-year lung cancer probability was higher in nodules ≥300 mm (RR 18.1, 95% CI 5.6-58.4; p < 0.001) and in upper lobe nodules (RR 2.7, 95% CI 1.3-5.5; p = 0.009).
[CONCLUSION] Solid and part-solid nodules with volume ≥300 mm were more often found in the upper lobes and were associated with a higher probability of lung cancer within a two-year follow-up period.
[METHODS] UKLS participants with baseline indeterminate and positive lung nodules were included. Nodule location was categorized by lobe and by attachment: intraparenchymal, juxta pleural or pleural-based. Solid and part-solid were classified based on semi-automated volume: 100-300 mm and ≥300 mm, and non-solid nodules based on diameter ≥8 mm. This measurement approach aligns with UKLS protocol and the British Thoracic Society (BTS) guideline. Their relationship to screen-detected lung cancer was based on histological outcomes after a 2-year follow-up period.
[RESULTS] 279 UKLS participants with 373 solid or part-solid lung nodules ≥100 mm and 57 participants with 62 nonsolid nodules ≥8 mm were included. Among solid and part-solid nodules, 233 were 100-300 mm, with 39.5% in upper lobes and 72.5% intraparenchymal; 140 nodules were ≥300 mm, with 51.4% in upper lobes and 53.6% intraparenchymal. Nodules ≥300 mm group were more likely to be in the upper lobes (OR 1.97 [95% CI 1.12-3.48]). Within 2 years, 34 solid or part-solid nodules were diagnosed as lung cancer, yielding a 2-year cancer probability of 9.1% (95% CI 6.6-12.5). The 2-year lung cancer probability was higher in nodules ≥300 mm (RR 18.1, 95% CI 5.6-58.4; p < 0.001) and in upper lobe nodules (RR 2.7, 95% CI 1.3-5.5; p = 0.009).
[CONCLUSION] Solid and part-solid nodules with volume ≥300 mm were more often found in the upper lobes and were associated with a higher probability of lung cancer within a two-year follow-up period.
MeSH Terms
Humans; Lung Neoplasms; Early Detection of Cancer; Female; Male; Middle Aged; Follow-Up Studies; Aged; United Kingdom; Multiple Pulmonary Nodules; Tomography, X-Ray Computed; Solitary Pulmonary Nodule; Mass Screening