Empirical Osimertinib as a Second-Line Treatment Is a Viable Option Following First- and Second-Generation TKI Therapy With Unknown EGFR Status in Treated Non-Small Cell Lung Cancer: A Retrospective Study.
2/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
160 patients with EGFR-mutated lung adenocarcinoma at clinical stages IIIB-IVB received first- or second-generation EGFR-TKI frontline therapy.
I · Intervention 중재 / 시술
first- or second-generation EGFR-TKI frontline therapy
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The RR of 42.7% and median ToT of 5.6 months appear consistent with historical outcomes reported for second-line platinum-based chemotherapy. Osimertinib provides an additional treatment line for patients whose tumors are difficult to access and have an unknown T790M status, making it a valuable treatment option for these patients.
OpenAlex 토픽 ·
Lung Cancer Treatments and Mutations
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Lung Cancer Diagnosis and Treatment
[BACKGROUND AND PURPOSE] Patients with advanced epidermal growth factor receptor (EGFR)-mutated adenocarcinoma often receive frontline first- and second-generation EGFR tyrosine kinase inhibitor (TKI)
- 95% CI 4.0-9.3
APA
Min‐Hsi Lin, Kuo‐An Chu, et al. (2026). Empirical Osimertinib as a Second-Line Treatment Is a Viable Option Following First- and Second-Generation TKI Therapy With Unknown EGFR Status in Treated Non-Small Cell Lung Cancer: A Retrospective Study.. Cancer medicine, 15(5), e71881. https://doi.org/10.1002/cam4.71881
MLA
Min‐Hsi Lin, et al.. "Empirical Osimertinib as a Second-Line Treatment Is a Viable Option Following First- and Second-Generation TKI Therapy With Unknown EGFR Status in Treated Non-Small Cell Lung Cancer: A Retrospective Study.." Cancer medicine, vol. 15, no. 5, 2026, pp. e71881.
PMID
42032945
Abstract
[BACKGROUND AND PURPOSE] Patients with advanced epidermal growth factor receptor (EGFR)-mutated adenocarcinoma often receive frontline first- and second-generation EGFR tyrosine kinase inhibitor (TKI) treatments in Taiwan. However, upon progression, not all patients undergo rebiopsy for molecular testing. In some cases, tumors are located in difficult-to-access areas, and some rebiopsy specimens are inadequate for pathological and molecular assessment. Our aim is to evaluate the efficacy of the third-generation EGFR TKI, osimertinib, in tumors with unknown T790M mutation status.
[METHODS] This study retrospectively collected data from patients with EGFR-mutant advanced lung adenocarcinoma who received first-line first- or second-generation EGFR TKI therapy followed by the third-generation EGFR TKI osimertinib without rebiopsy to assess T790M mutation status between January 2015 and December 2024. Efficacy and survival outcomes are presented.
[RESULTS] A total of 160 patients with EGFR-mutated lung adenocarcinoma at clinical stages IIIB-IVB received first- or second-generation EGFR-TKI frontline therapy. After disease progression, 82 patients were treated with osimertinib as a second-line therapy with unknown T790M mutation status. Among them, 48 patients initially received afatinib as frontline treatment, while 34 patients received erlotinib. The best tumor response rate (RR) was 42.7%, with a median time on treatment (ToT) of 5.6 months (95% CI, 4.0-9.3). Swim-plot visualization highlighted a hierarchical pattern wherein longer first-line duration frequently co-occurred with longer empirical second-line duration.
[CONCLUSION] Osimertinib treatment is a viable option for patients who progress on frontline first- or second-generation EGFR TKI therapy without rebiopsy and have an unknown T790M mutation status. The RR of 42.7% and median ToT of 5.6 months appear consistent with historical outcomes reported for second-line platinum-based chemotherapy. Osimertinib provides an additional treatment line for patients whose tumors are difficult to access and have an unknown T790M status, making it a valuable treatment option for these patients.
[METHODS] This study retrospectively collected data from patients with EGFR-mutant advanced lung adenocarcinoma who received first-line first- or second-generation EGFR TKI therapy followed by the third-generation EGFR TKI osimertinib without rebiopsy to assess T790M mutation status between January 2015 and December 2024. Efficacy and survival outcomes are presented.
[RESULTS] A total of 160 patients with EGFR-mutated lung adenocarcinoma at clinical stages IIIB-IVB received first- or second-generation EGFR-TKI frontline therapy. After disease progression, 82 patients were treated with osimertinib as a second-line therapy with unknown T790M mutation status. Among them, 48 patients initially received afatinib as frontline treatment, while 34 patients received erlotinib. The best tumor response rate (RR) was 42.7%, with a median time on treatment (ToT) of 5.6 months (95% CI, 4.0-9.3). Swim-plot visualization highlighted a hierarchical pattern wherein longer first-line duration frequently co-occurred with longer empirical second-line duration.
[CONCLUSION] Osimertinib treatment is a viable option for patients who progress on frontline first- or second-generation EGFR TKI therapy without rebiopsy and have an unknown T790M mutation status. The RR of 42.7% and median ToT of 5.6 months appear consistent with historical outcomes reported for second-line platinum-based chemotherapy. Osimertinib provides an additional treatment line for patients whose tumors are difficult to access and have an unknown T790M status, making it a valuable treatment option for these patients.