[Research progress on intervention of "inflammation-cancer transformation" of chronic gastritis through regulation of NF-κB-related signaling pathways by traditional Chinese medicine].

Chronic gastritis, a chronic and insidious inflammatory condition of the gastric mucosa, is characterized by nonspecific early symptoms and a high risk of progression to gastric cancer. Persistent inflammatory stimulation accelerates the "inflammation-cancer transformation" by remodeling the microenvironment, and suppressing this process is critical for gastric cancer prevention and treatment. Nuclear factor-κB(NF-κB) serves not only as a central hub for inflammatory regulation but also as a key node connecting pathways such as Toll-like receptor 4(TLR4), NOD-like receptor protein 3(NLRP3), mitogen-activated protein kinase(MAPK), signal transducer and activator of transcription 3(STAT3), and protein kinase B(AKT). Extensive studies have demonstrated that monomers and herbal formulas in traditional Chinese medicine(TCM) can modulate NF-κB-related signaling pathways to mitigate the progression of "inflammation-cancer transformation" of chronic gastritis, achieving multi-level, multi-target intervention in gastric cancer. Based on this, this article systematically reviewed the dynamic network of NF-κB and relevant crosstalk pathways in "inflammation-cancer transformation" and the mechanisms of TCM-based interventions, providing theoretical foundations for optimizing clinical strategies and advancing gastric cancer prevention.