[Pathogenesis of "inflammation-cancer transformation" in chronic pancreatitis and three-stage entropy reduction for prevention and treatment based on entropy disease theory].

Pancreatic cancer(PC) is a highly malignant tumor of digestive system, and it is called "the king of cancer". Chronic pancreatitis(CP) is a high-risk factor for PC. The mechanism of "inflammation-cancer transformation" of CP and its prevention and treatment strategies are the focus of current research. Based on the second law of thermodynamics, the entropy disease theory reveals that the essence of disease is the disorder caused by the increase of entropy. The theoretical connotation of entropy disease is consistent with the pathogenesis of "inflammation-cancer transformation" in CP. The entropy disease theory clarifies that the "inflammation-cancer transformation" of CP is essentially an entropy-increasing process from a relatively orderly pathological state to a highly disordered cancerous state. In the initial stage, the spleen is weak with endogenous dampness accumulation, forming damp heat. This causes the disorder of energy metabolism and leads to the gradual increase of entropy value in the body. At the critical stage, phlegm and blood stasis stagnate each other, resulting in the microenvironment homeostasis imbalance of pancreatic tissue, which leads to the acceleration of the increase of entropy. In the qualitative change stage, the Qi in the body is blocked, and the cancer toxin is generated and accumulated, which leads to the collapse of the body's regulatory mechanism and the rise of entropy in the body until it breaks through the critical threshold. This eventually causes the formation of pancreatic cancer. In terms of treatment, this paper put forward a three-stage entropy reduction strategy for prevention and treatment, which involves clearing away dampness and heat, invigorating the spleen and regulating the stomach, resolving phlegm and eliminating stagnation, promoting blood circulation and removing blood stasis, and regulating the smooth operation of Qi and clearing away cancer toxin. These treatments can effectively block the occurrence of PC by correcting the disorder of energy metabolism, improving the imbalance of pancreatic microenvironment, and restoring the regulatory function of the body. Therefore, from the perspective of integrated traditional Chinese medicine and western medicine, this paper analyzed the internal relationship between entropy disease theory and "inflammation-cancer transformation" of CP, providing innovative ideas and a theoretical basis for early intervention and prevention of "inflammation-cancer transformation" of CP and holding important clinical application value and research significance.