Parity and lactation induce T-cell-mediated breast cancer protection.
1/5 보강
Parity and breastfeeding reduce the risk of breast cancer, particularly triple-negative breast cancer (TNBC), yet the immunological mechanisms underlying this protection remain unclear.
APA
Virassamy B, Caramia F, et al. (2026). Parity and lactation induce T-cell-mediated breast cancer protection.. Nature, 649(8096), 449-459. https://doi.org/10.1038/s41586-025-09713-5
MLA
Virassamy B, et al.. "Parity and lactation induce T-cell-mediated breast cancer protection.." Nature, vol. 649, no. 8096, 2026, pp. 449-459.
PMID
41115453 ↗
Abstract 한글 요약
Parity and breastfeeding reduce the risk of breast cancer, particularly triple-negative breast cancer (TNBC), yet the immunological mechanisms underlying this protection remain unclear. Here we show that parity is associated with increased numbers of CD8 T cells, including cells with a tissue-resident-memory-like phenotype within human normal breast tissue. In mouse models, pregnancy followed by lactation and involution drove the accumulation of CD8 T cells in the mammary gland, coinciding with reduced tumour growth and increased intratumoural immune cell infiltration, effects that were abrogated by CD8 T cell depletion. Importantly, this CD8 T-cell-dependent tumour control was observed only after a complete cycle of lactation and involution. Consistent with this, primary triple-negative breast cancers from parous women exhibited greater T cell infiltration and improved clinical outcomes. Together, these findings, spanning preclinical models and over 1,000 patient samples, provide insights into how reproductive history shapes breast immunity, positioning CD8 T cells as key mediators of parity-associated protection and informing strategies for both the prevention and the treatment of breast cancer.
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