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Interassay Comparison With Digital Image Analysis of 4 Routine Human Epidermal Growth Factor Receptor 2 (HER2) Immunohistochemistry Assays in Primary Breast Cancer and Its Metastasis.

1/5 보강

Laboratory investigation; a journal of technical methods and pathology 📖 저널 OA 7.9% 2023~2026 2026 Vol.106(1) p. 104261

PICO 자동 추출 (휴리스틱, conf 2/4)

P · Population 대상 환자/모집단

193 patients with breast cancer who participated in the IMaging PAtients for Cancer drug selecTion-Metastatic Breast Cancer trial were incorporated into 6 tissue microarrays.

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

DG44 identified a significantly higher proportion of HER2-(ultra)low cases and showed the most variability in HER2 status between matched primary tumors and metastases compared with 4B5 and SP3. The choice of HER2 assay can lead to discrepancies in HER2 status assessment, which could directly influence patient eligibility for trastuzumab-deruxtecan treatment.

Hempenius MA, Zwager MC, Thagaard J, Slagter-Menkema L, Buikema HJ, Barbé E

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