A novel mechanism of immunoevasion by ER breast cancer.

Galassi C; Galluzzi L

doi:10.1016/j.it.2025.12.003

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A novel mechanism of immunoevasion by ER breast cancer.

Trends in immunology 2026 Vol.47(1) p. 6-8

Galassi C, Galluzzi L

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Estrogen receptor (ER) breast malignancies are poorly infiltrated by immune cells, hence exhibiting limited sensitivity to immune checkpoint inhibitors (ICIs).

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APA Galassi C, Galluzzi L (2026). A novel mechanism of immunoevasion by ER breast cancer.. Trends in immunology, 47(1), 6-8. https://doi.org/10.1016/j.it.2025.12.003

MLA Galassi C, et al.. "A novel mechanism of immunoevasion by ER breast cancer.." Trends in immunology, vol. 47, no. 1, 2026, pp. 6-8.

PMID 41412836

DOI 10.1016/j.it.2025.12.003

Abstract

Estrogen receptor (ER) breast malignancies are poorly infiltrated by immune cells, hence exhibiting limited sensitivity to immune checkpoint inhibitors (ICIs). Recent data from Palomeque et al. demonstrate that ER signaling actively contributes to such an immunoevasive phenotype by preventing the nuclear factor LCOR from establishing an ICI-sensitive tumor microenvironment.

MeSH Terms

Humans; Breast Neoplasms; Female; Tumor Microenvironment; Receptors, Estrogen; Immune Checkpoint Inhibitors; Tumor Escape; Signal Transduction; Animals