insight
✂️ 성형 🏥 중증 🌐 전체
← 뒤로

OTU deubiquitinases in disease: roles and targeting.

Trends in molecular medicine 2026 Vol.32(1) p. 84-97

Deng Y, Liu P

PMC 전문 ↗ 원문 ↗ DOI ↗ BibTeX ↓ RIS ↓
📝 환자 설명용 한 줄

Dysregulation of protein homeostasis contributes to many human diseases and is an emerging therapeutic target.

이 논문을 인용하기

BibTeX ↓ RIS ↓
APA Deng Y, Liu P (2026). OTU deubiquitinases in disease: roles and targeting.. Trends in molecular medicine, 32(1), 84-97. https://doi.org/10.1016/j.molmed.2025.05.006
MLA Deng Y, et al.. "OTU deubiquitinases in disease: roles and targeting.." Trends in molecular medicine, vol. 32, no. 1, 2026, pp. 84-97.
PMID 40527635
DOI 10.1016/j.molmed.2025.05.006

Abstract

Dysregulation of protein homeostasis contributes to many human diseases and is an emerging therapeutic target. Proteasome-mediated degradation requires ubiquitin tagging, a process regulated by E3 ligases and reversed by deubiquitinases (DUBs). Among DUBs, the ovarian tumor protease (OTU) family exhibits poly-ubiquitin linkage-specific activity and regulates diverse cellular processes. OTU dysregulation has been linked to diseases such as cancer, highlighting their potential as drug targets. This review summarizes current knowledge of OTU functions, regulatory mechanisms, and disease associations, as well as therapeutic strategies targeting OTUs. By examining these aspects, we aim to provide insights into the pathophysiological roles of OTUs and support ongoing efforts to develop OTU-targeted therapies for human diseases.

MeSH Terms

Humans; Deubiquitinating Enzymes; Animals; Neoplasms; Molecular Targeted Therapy; Ubiquitination

같은 제1저자의 인용 많은 논문 (5)