Germline Variations in Patients With Oral Squamous Cell Carcinoma-Systematic Review.
메타분석
1/5 보강
[OBJECTIVE] Integrate studies on germline variations (GV) in patients with oral squamous cell carcinoma (OSCC), aiming to assess the highest frequencies of which genes were altered in patients with th
- 연구 설계 case-control
APA
Dutra MJ, Schuch LF, et al. (2026). Germline Variations in Patients With Oral Squamous Cell Carcinoma-Systematic Review.. Oral diseases, 32(1), 17-24. https://doi.org/10.1111/odi.70040
MLA
Dutra MJ, et al.. "Germline Variations in Patients With Oral Squamous Cell Carcinoma-Systematic Review.." Oral diseases, vol. 32, no. 1, 2026, pp. 17-24.
PMID
40684456 ↗
Abstract 한글 요약
[OBJECTIVE] Integrate studies on germline variations (GV) in patients with oral squamous cell carcinoma (OSCC), aiming to assess the highest frequencies of which genes were altered in patients with this diagnosis.
[METHODS] An electronic search was conducted in four databases and in the gray literature, following the PRISMA 2020 recommendations. Case reports, case series, case-control studies, cross-sectional studies, prospective cohort studies, and retrospective cohort studies reporting GV in patients with OSCC were included for data extraction.
[RESULTS] Twenty articles were included, covering 146 cases of OSCC. Patients had a mean age of 47.5 years; the majority were male, non-drinkers, and non-smokers. For most cases, p16 staining and human papilloma virus (HPV) status were not investigated/reported. A total of 231 different GV genes were identified in the 146 patients, with the most frequently altered being ND5 (6.1%), CYTB (4.8%), COX1 (4.6%), PDE4DIP (4.1%), ND1 (3.9%), ND4 (3.2%), ND2 (2.7%), ATP6 (2.7%), CDKN2A (2.6%), COX2 (2.4%), COX3 (2.2%), and ND3 and ND6, both accounting for 2% each.
[CONCLUSION] This review compiles important data on the most frequent GV in patients with OSCC, enabling new understandings of oral carcinogenesis, as well as future directions for prognosis and treatment.
[METHODS] An electronic search was conducted in four databases and in the gray literature, following the PRISMA 2020 recommendations. Case reports, case series, case-control studies, cross-sectional studies, prospective cohort studies, and retrospective cohort studies reporting GV in patients with OSCC were included for data extraction.
[RESULTS] Twenty articles were included, covering 146 cases of OSCC. Patients had a mean age of 47.5 years; the majority were male, non-drinkers, and non-smokers. For most cases, p16 staining and human papilloma virus (HPV) status were not investigated/reported. A total of 231 different GV genes were identified in the 146 patients, with the most frequently altered being ND5 (6.1%), CYTB (4.8%), COX1 (4.6%), PDE4DIP (4.1%), ND1 (3.9%), ND4 (3.2%), ND2 (2.7%), ATP6 (2.7%), CDKN2A (2.6%), COX2 (2.4%), COX3 (2.2%), and ND3 and ND6, both accounting for 2% each.
[CONCLUSION] This review compiles important data on the most frequent GV in patients with OSCC, enabling new understandings of oral carcinogenesis, as well as future directions for prognosis and treatment.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (1)
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.