Cytotoxic Chemotherapy Worsens Iron Deficiency Anaemia among Indian Women with Non - Metastatic Breast Cancer.
[PURPOSE] Assessment of the effect of cytotoxic chemotherapy on the indices of iron homeostasis to elucidate the aetiology of anaemia in breast cancer.
APA
Saroja K, Bobby Z, et al. (2026). Cytotoxic Chemotherapy Worsens Iron Deficiency Anaemia among Indian Women with Non - Metastatic Breast Cancer.. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 42(1), 146-153. https://doi.org/10.1007/s12288-025-01972-6
MLA
Saroja K, et al.. "Cytotoxic Chemotherapy Worsens Iron Deficiency Anaemia among Indian Women with Non - Metastatic Breast Cancer.." Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, vol. 42, no. 1, 2026, pp. 146-153.
PMID
41522535
Abstract
[PURPOSE] Assessment of the effect of cytotoxic chemotherapy on the indices of iron homeostasis to elucidate the aetiology of anaemia in breast cancer.
[METHODS] Forty-two newly diagnosed breast cancer patients with Hb > 10 g/dL were recruited. Iron indices were estimated before and after neoadjuvant chemotherapy (NACT). Anaemia of chronic disease (ACD) and anaemia of chronic disease + iron deficiency anaemia (IDA) were identified by sTfR, sTfR index, and algorithm by Skikne et al.
[RESULTS] Anaemia was 52% at the presentation time, which increased to 93% at the end of NACT. Among the anaemic breast cancer patients, 75% belonged to the group of ACD + IDA, and only 25% belonged to the group of ACD at the time of presentation. After NACT, the number of patients in the ACD + IDA group significantly increased to 93%, while the members of the ACD group significantly reduced to 7%. Ferritin, Hepcidin, Transferrin, sTfR, and sTfR index increased after NACT.
[CONCLUSION] The primary aetiology of anaemia among Indian breast cancer patients is a combination of ACD and IDA. Indian breast cancer patients were more vulnerable to developing iron deficiency anaemia when compared to anaemia of chronic disease during NACT.
[METHODS] Forty-two newly diagnosed breast cancer patients with Hb > 10 g/dL were recruited. Iron indices were estimated before and after neoadjuvant chemotherapy (NACT). Anaemia of chronic disease (ACD) and anaemia of chronic disease + iron deficiency anaemia (IDA) were identified by sTfR, sTfR index, and algorithm by Skikne et al.
[RESULTS] Anaemia was 52% at the presentation time, which increased to 93% at the end of NACT. Among the anaemic breast cancer patients, 75% belonged to the group of ACD + IDA, and only 25% belonged to the group of ACD at the time of presentation. After NACT, the number of patients in the ACD + IDA group significantly increased to 93%, while the members of the ACD group significantly reduced to 7%. Ferritin, Hepcidin, Transferrin, sTfR, and sTfR index increased after NACT.
[CONCLUSION] The primary aetiology of anaemia among Indian breast cancer patients is a combination of ACD and IDA. Indian breast cancer patients were more vulnerable to developing iron deficiency anaemia when compared to anaemia of chronic disease during NACT.