Impact of elective cervical dissection on the prognosis of patients with oral squamous cell carcinoma cT1/T2N0: A systematic review and meta-analysis.
메타분석
1/5 보강
[OBJECTIVE] The therapeutic approach for patients with early T-stage (T1-T2) oral squamous cell carcinoma (OSCC) and a clinically negative neck (N0) remains a subject of debate in clinical practice.
- p-value p < 0.001
- p-value p = 0.015
- 95% CI 0.28-0.77
- RR 0.47
- 연구 설계 systematic review
APA
Binda NC, Lavareze L, et al. (2026). Impact of elective cervical dissection on the prognosis of patients with oral squamous cell carcinoma cT1/T2N0: A systematic review and meta-analysis.. Critical reviews in oncology/hematology, 217, 104982. https://doi.org/10.1016/j.critrevonc.2025.104982
MLA
Binda NC, et al.. "Impact of elective cervical dissection on the prognosis of patients with oral squamous cell carcinoma cT1/T2N0: A systematic review and meta-analysis.." Critical reviews in oncology/hematology, vol. 217, 2026, pp. 104982.
PMID
41115617 ↗
Abstract 한글 요약
[OBJECTIVE] The therapeutic approach for patients with early T-stage (T1-T2) oral squamous cell carcinoma (OSCC) and a clinically negative neck (N0) remains a subject of debate in clinical practice. This systematic review and meta-analysis aimed to compare elective neck dissection (END) and observation (OBS) in early T-stage OSCC.
[METHODS] A search was performed on March 25, 2025, in the PubMed, Scopus, EMBASE, Web of Science, LILACS databases, and gray literature (Google Scholar, OpenGrey, ProQuest). Studies comparing END and OBS in patients with cT1-2N0 OSCC were included. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal tool. Quantitative data from eligible studies were pooled through meta-analysis using random-effects models in R software to estimate relative risks and 95 % confidence intervals for the main outcomes.
[RESULTS] Seventeen studies (2263 patients) were included. Elective neck dissection (END) was associated with a significant reduction in the risk of regional nodal recurrence (RR = 0.47; 95 % CI: 0.28-0.77; p < 0.001), as well as improved overall survival (RR = 0.75; 95 % CI: 0.60-0.95; p = 0.015) and disease-specific survival (RR = 1.32; 95 % CI: 1.21-1.45; p < 0.001) compared to observation in patients with early-stage OSCC.
[CONCLUSION] END is associated with a significant reduction in nodal recurrence rates and improved overall and DSS compared to OBS in patients with early-stage OSCC (cT1-2N0).
[METHODS] A search was performed on March 25, 2025, in the PubMed, Scopus, EMBASE, Web of Science, LILACS databases, and gray literature (Google Scholar, OpenGrey, ProQuest). Studies comparing END and OBS in patients with cT1-2N0 OSCC were included. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal tool. Quantitative data from eligible studies were pooled through meta-analysis using random-effects models in R software to estimate relative risks and 95 % confidence intervals for the main outcomes.
[RESULTS] Seventeen studies (2263 patients) were included. Elective neck dissection (END) was associated with a significant reduction in the risk of regional nodal recurrence (RR = 0.47; 95 % CI: 0.28-0.77; p < 0.001), as well as improved overall survival (RR = 0.75; 95 % CI: 0.60-0.95; p = 0.015) and disease-specific survival (RR = 1.32; 95 % CI: 1.21-1.45; p < 0.001) compared to observation in patients with early-stage OSCC.
[CONCLUSION] END is associated with a significant reduction in nodal recurrence rates and improved overall and DSS compared to OBS in patients with early-stage OSCC (cT1-2N0).
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.