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PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

1/5 보강

Clinical cancer research : an official journal of the American Association for Cancer Research 📖 저널 OA 54.8% 2022~2026 2026 Vol.32(1) p. 56-75

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: PIK3CA-mutated solid tumors to determine the maximum tolerated dose and safety

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

[CONCLUSIONS] These findings highlight a novel cooperativity between FGFR2 and p110α that boosts the effectiveness of inavolisib. The data support advancing precision oncology beyond single biomarkers to complex algorithms utilizing co-occurring alterations, suggesting that combining inavolisib with FGFR2 inhibitors may offer enhanced and more durable responses in PIK3CA/FGFR2-altered tumors.

Juric D, Song K, Johnson RM, Accordino MK, Bedard PL, Cervantes A

📖 무료 전문 🟢 PMC 전문 PMC12770939

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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