Antibody-drug conjugates in oncology: A spotlight on overcoming resistance.
1/5 보강
Antibody-drug conjugates (ADCs), which combine precise monoclonal antibodies with cytotoxic payloads, represent a transformative class of anticancer therapeutics.
APA
Xu X, Yu T, Wang Z (2026). Antibody-drug conjugates in oncology: A spotlight on overcoming resistance.. Critical reviews in oncology/hematology, 217, 105015. https://doi.org/10.1016/j.critrevonc.2025.105015
MLA
Xu X, et al.. "Antibody-drug conjugates in oncology: A spotlight on overcoming resistance.." Critical reviews in oncology/hematology, vol. 217, 2026, pp. 105015.
PMID
41223981 ↗
Abstract 한글 요약
Antibody-drug conjugates (ADCs), which combine precise monoclonal antibodies with cytotoxic payloads, represent a transformative class of anticancer therapeutics. Despite their clinical success, resistance mechanisms significantly limit their therapeutic utility. This review systematically summarizes the multifaceted mechanisms underlying ADC resistance, including antibody-related factors, aberrant intracellular trafficking, payload-related factors, and dysregulated survival signaling. We further evaluated strategies to overcome resistance, including third-generation ADCs, novel payloads, and multimodal combination therapies. By integrating preclinical insights and clinical advancements, this review provides a theoretical framework for optimizing ADC efficacy and overcoming therapeutic resistance in oncology.
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