Periodontitis and Systemic Health: An Interconnected Relationship.

The oral-systemic health connection refers to the bidirectional relationship between oral health and overall systemic health. Emerging research has shown that periodontal diseases, such as gingivitis and periodontitis, are linked to a range of systemic conditions, including cardiovascular disease (CVD), diabetes mellitus, adverse pregnancy outcomes (APOs), and cancer. The pathogenesis of periodontitis involves complex host-microbe interactions, which can lead to periodontal tissue destruction and systemic inflammation. Bacterial translocation and the systemic spread of pro-inflammatory mediators, such as lipopolysaccharides and cytokines, are explored as potential pathways linking oral to systemic health.In this chapter, the evidence from epidemiological and clinical studies supporting these associations is reviewed, addressing the limitations and controversies in existing research and emphasizing the mechanistic evidence for a possible causal relationship. Additionally, it discusses the impact of improving periodontal health on managing systemic conditions, presenting periodontal treatment as a potential adjunctive therapy to reduce systemic disease risk and severity.