Diagnostic potential of serum humanin in breast cancer among the Egyptian population.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: primary non-metastatic breast cancer and 70 age-matched healthy controls of comparable age were enrolled in this study
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] These findings suggest that humanin could serve as a promising biomarker for breast cancer screening and early detection. Further large-scale studies are warranted to validate its diagnostic potential and establish its clinical utility.
[BACKGROUND] Globally, breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women.
- p-value p < 0.001
- Sensitivity 78.7%
- Specificity 62.9%
APA
Mohamed MH, Kamel WT, et al. (2026). Diagnostic potential of serum humanin in breast cancer among the Egyptian population.. Discover oncology, 17(1), 160. https://doi.org/10.1007/s12672-025-04325-x
MLA
Mohamed MH, et al.. "Diagnostic potential of serum humanin in breast cancer among the Egyptian population.." Discover oncology, vol. 17, no. 1, 2026, pp. 160.
PMID
41518474
Abstract
[BACKGROUND] Globally, breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women. The ongoing pursuit of early detection has driven interest in identifying and validating novel diagnostic biomarkers that could enhance prognosis and therapeutic outcomes. Humanin, a mitochondrial-derived peptide (MDP) with reported cytoprotective properties, has been implicated in cancer biology and may play a role in breast cancer pathogenesis.
[METHODS] A total of 75 female patients with primary non-metastatic breast cancer and 70 age-matched healthy controls of comparable age were enrolled in this study. Serum concentrations of humanin were quantified using an enzyme-linked immunosorbent assay (ELISA).
[RESULTS] Serum humanin concentrations were significantly elevated in breast cancer patients compared with healthy controls (p < 0.001). Receiver operating characteristic (ROC) curve analysis demonstrated that humanin effectively differentiated breast cancer patients from controls, with a sensitivity of 78.7% and specificity of 62.9%.
[CONCLUSION] These findings suggest that humanin could serve as a promising biomarker for breast cancer screening and early detection. Further large-scale studies are warranted to validate its diagnostic potential and establish its clinical utility.
[METHODS] A total of 75 female patients with primary non-metastatic breast cancer and 70 age-matched healthy controls of comparable age were enrolled in this study. Serum concentrations of humanin were quantified using an enzyme-linked immunosorbent assay (ELISA).
[RESULTS] Serum humanin concentrations were significantly elevated in breast cancer patients compared with healthy controls (p < 0.001). Receiver operating characteristic (ROC) curve analysis demonstrated that humanin effectively differentiated breast cancer patients from controls, with a sensitivity of 78.7% and specificity of 62.9%.
[CONCLUSION] These findings suggest that humanin could serve as a promising biomarker for breast cancer screening and early detection. Further large-scale studies are warranted to validate its diagnostic potential and establish its clinical utility.