Enhanced Anticancer Efficacy of Novel Asiminatide A Isolated from in Triple-Negative Breast Cancer.
1/5 보강
Cyclopeptides are promising anticancer agents due to their ability to regulate multiple signaling pathways.
APA
Li Z, Saravanakumar K, et al. (2026). Enhanced Anticancer Efficacy of Novel Asiminatide A Isolated from in Triple-Negative Breast Cancer.. Biomacromolecules, 27(1), 702-715. https://doi.org/10.1021/acs.biomac.5c01953
MLA
Li Z, et al.. "Enhanced Anticancer Efficacy of Novel Asiminatide A Isolated from in Triple-Negative Breast Cancer.." Biomacromolecules, vol. 27, no. 1, 2026, pp. 702-715.
PMID
41457563 ↗
Abstract 한글 요약
Cyclopeptides are promising anticancer agents due to their ability to regulate multiple signaling pathways. In this study, a novel cyclopeptide, Asiminatide A (AA), was isolated from , and a nanodrug delivery system (nDDS) was developed to enhance its efficacy against triple-negative breast cancer (TNBC). High-resolution time-of-flight mass spectrometer (HR-TOF-MS) and H/C NMR analyses identified AA as a cyclic heptapeptide composed of Pro-Val-Phe-Ile-Ser-Ile-Gly. AA was encapsulated into folic-acid-conjugated chitosan nanoparticles (AA-FA-CS NPs), as confirmed by H NMR and Fourier-transform infrared spectroscopy (FTIR). The nanoparticles exhibited pH-responsive drug release with enhanced release at pH 5.2. studies showed that dual pH- and folate receptor-targeted delivery significantly enhanced cytotoxicity in MDA-MB-231 cells via oxidative stress and nuclear damage while maintaining good biocompatibility. , AA-FA-CS NPs effectively suppressed tumor growth without any evident organ toxicity. These results demonstrate the anticancer potential of AA enabled by nanodelivery.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- Botulinum Toxin Treatment for Calf Contouring Based on the Study of Combined Injection of Gastrocnemius and Soleus.
- The "Visible" Muscles on Ultrasound Imaging Make Botulinum Toxin Injection More Precise: A Systematic Review.
- Ultrasonographic observation of the masseter muscle after injection of different botulinum toxin type A.
- The cell yields and biological characteristics of stromal/stem cells from lipoaspirate with different digestion loading ratio.
- Panfacial Fat Injection Approach in Young Asian Patients for Facial Contouring: A Goal-Oriented Classification Method Based on the Facial Fat Compartments Theory.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.