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Taking imaging into the fourth dimension.

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Pathologie (Heidelberg, Germany) 📖 저널 OA 36.4% 2025: 4/14 OA 2026: 8/19 OA 2025~2026 2026 Vol.47(Suppl 1) p. 59-61
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Hansmann ML

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[BACKGROUND] Hematopathology is rapidly advancing.

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APA Hansmann ML (2026). Taking imaging into the fourth dimension.. Pathologie (Heidelberg, Germany), 47(Suppl 1), 59-61. https://doi.org/10.1007/s00292-025-01503-0
MLA Hansmann ML. "Taking imaging into the fourth dimension.." Pathologie (Heidelberg, Germany), vol. 47, no. Suppl 1, 2026, pp. 59-61.
PMID 41369744 ↗

Abstract

[BACKGROUND] Hematopathology is rapidly advancing. Combining structural, molecular, and dynamic analyses enables a deeper understanding of immune reactions and malignant lymphomas.

[MATERIALS AND METHODS] Three-dimensional (3D) imaging uses fluorescence-stained tissue sections with confocal microscopy. Four-dimensional (4D) live tissue slices allow real-time visualization of immune cell movement. Drugs can be tested directly on fresh samples.

[RESULTS] Three-dimensional images show key immune cell types; 4D imaging reveals cell-cell interactions. Nivolumab, for example, prolonged T cell contact with Hodgkin cells.

[CONCLUSION] Four-dimensional technology improves early disease detection, treatment monitoring, and drug development, bridging between molecular findings and clinical applications.

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