Immunotherapies in autoimmune neuromuscular junction disorders: Acute and chronic management.
1/5 보강
Myasthenia gravis (MG) is the most common disease of the neuromuscular junction.
APA
Evoli A, Gilhus NE, Sanders DB (2026). Immunotherapies in autoimmune neuromuscular junction disorders: Acute and chronic management.. Handbook of clinical neurology, 214, 395-415. https://doi.org/10.1016/B978-0-323-90887-0.00011-0
MLA
Evoli A, et al.. "Immunotherapies in autoimmune neuromuscular junction disorders: Acute and chronic management.." Handbook of clinical neurology, vol. 214, 2026, pp. 395-415.
PMID
41526148 ↗
Abstract 한글 요약
Myasthenia gravis (MG) is the most common disease of the neuromuscular junction. Conventional immunotherapy based on corticosteroids and immunosuppressants has been in use for several decades and has greatly contributed to the improvement of the disease prognosis. In recent years, several new agents, mostly monoclonal antibodies, have proved effective in randomized controlled trials and are in clinical use. Other biologics are currently under evaluation. Novel therapies, that offer the advantage of more selective effects on the immune system, are not devoid of potentially serious adverse effects. MG subgrouping based on associated autoantibodies is a prerequisite for personalized treatment. Patient-specific selection is especially relevant and includes MG-specific IgG subclasses and B-cell subsets responsible for antibody production. While ever-growing knowledge of the disease pathogenicity and advances in technology have made such therapeutic advances possible, lack of biomarkers of disease activity complicates treatment decisions. On the other hand, treatment of Lambert-Eaton myasthenic syndrome (LEMS) has scarcely changed in recent decades and biologics have been tried in very few patients to date. Its rarity and association with cancer have likely discouraged the exploration of new immunotherapies for LEMS despite disease-related disability.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.