Double refractory chronic lymphocytic leukemia: clinical scenarios and therapeutic strategies.
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Despite its typically indolent course in most patients, chronic lymphocytic leukemia (CLL) can relapse or become refractory to the two main classes of drugs commonly used: covalent BTK inhibitors and
APA
Mozas P, Quintela D, Serna Á (2026). Double refractory chronic lymphocytic leukemia: clinical scenarios and therapeutic strategies.. Medicina clinica, 166(1), 107288. https://doi.org/10.1016/j.medcli.2025.107288
MLA
Mozas P, et al.. "Double refractory chronic lymphocytic leukemia: clinical scenarios and therapeutic strategies.." Medicina clinica, vol. 166, no. 1, 2026, pp. 107288.
PMID
41538902 ↗
Abstract 한글 요약
Despite its typically indolent course in most patients, chronic lymphocytic leukemia (CLL) can relapse or become refractory to the two main classes of drugs commonly used: covalent BTK inhibitors and BCL2 inhibitors. This review outlines the potential reasons for discontinuation of these drug classes, defines the concepts of double exposure (DE) and double refractoriness (DR), delineates the possible treatment sequences leading to DR, summarizes the poor prognosis of this patient subgroup, and describes the approved, investigational, and less optimal therapeutic alternatives for the management of this population. Finally, three illustrative clinical vignettes of patients with DE/DR CLL are presented, including case analysis and practical management recommendations, as well as teaching points.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Leukemia
- Lymphocytic
- Chronic
- B-Cell
- Drug Resistance
- Neoplasm
- Protein Kinase Inhibitors
- Agammaglobulinaemia Tyrosine Kinase
- Proto-Oncogene Proteins c-bcl-2
- Antineoplastic Agents
- Aged
- Male
- Female
- Antineoplastic Combined Chemotherapy Protocols
- Middle Aged
- BTK degrader
- CAR-T cell therapy
- Chronic lymphocytic leukemia
- Degradador de BTK
- Doble refractaria
- Double refractory
- Immunotherapy
- Inhibidor de BTK no covalente
… 외 6개
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