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Changes in the classification of malignant salivary gland tumours across the last three WHO editions.

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Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia 2026 Vol.59(1) p. 100857
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Rojas-Alcayaga G, Pinto Ávila M, Cáceres Villanueva F, Vargas Piña I, Yutronic Adasme C, Gallegos Méndez I

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This article explores the evolution of the classification of malignant salivary gland tumours (MSGTs) over the years, focusing on the last three editions of the World Health Organization (WHO) texts-t

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APA Rojas-Alcayaga G, Pinto Ávila M, et al. (2026). Changes in the classification of malignant salivary gland tumours across the last three WHO editions.. Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia, 59(1), 100857. https://doi.org/10.1016/j.patol.2026.100857
MLA Rojas-Alcayaga G, et al.. "Changes in the classification of malignant salivary gland tumours across the last three WHO editions.." Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia, vol. 59, no. 1, 2026, pp. 100857.
PMID 41576609

Abstract

This article explores the evolution of the classification of malignant salivary gland tumours (MSGTs) over the years, focusing on the last three editions of the World Health Organization (WHO) texts-the third, fourth and fifth editions. It describes changes in the nomenclature of entities, the incorporation of new entities, and the removal of others. The reasons underlying the modification of existing entity names are also presented, along with an examination of the rationale for their exclusion from the classification and the persistence of these designations in the scientific literature, as well as in clinical and academic discussions. In addition, the nature and clinicopathological characteristics of the newly recognised entities are examined. This detailed analysis not only documents the observed changes but also provides insight into the reasons justifying them and the clinical implications associated with the evolving classification of these tumours.

MeSH Terms

Humans; Salivary Gland Neoplasms; World Health Organization; Terminology as Topic