The AMICO Clinic Approach to Integrative Oncology in Breast Cancer Care: Structure and Clinical Framework From a Southern Italian Hospital.

With increasing survival rates for breast cancer (BC)-91% at 5 years and 80% at 15 years post-diagnosis-there is growing recognition of the importance of addressing long-term patient well-being. Beyond standard medical treatments, factors such as diet, psychological health, and quality of life significantly impact BC outcomes. Integrative oncology, which combines conventional oncology therapies with evidence-based complementary approaches (including nutrition, mind-body practices, and lifestyle modifications), has emerged as a patient-centered model aimed at improving symptom management, treatment adherence, and overall quality of life. This work describes the introduction of integrative oncology practices through the "AMICO" clinic, located within the Breast Surgery Unit at IRCCS-CROB in Rionero in Vulture, Southern Italy. As the first initiative of its kind in a public hospital in Italy, the clinic aims to provide a patient-centered approach for BC patients undergoing chemotherapy, radiation therapy, and/or breast surgery, with the mission to alleviate common side effects and improve their quality of life. During its first year of activity, the clinic has conducted joint consultations with nutritionists, organized mind-body laboratories (including Qigong sessions) and collected real-time clinical data These activities provide a foundation for the development of robust clinical databases and support a structured approach to patient-centered integrative care. By combining conventional oncology with evidence-based complementary therapies, the AMICO Clinic provides an example of a structured approach to personalization of cancer care. Ongoing and future research will further clarify the clinical value and potential benefits of integrative oncology in enhancing patient well-being.