Dual anticancer and immunoregulatory actions of blueberry stem extract in breast cancer cells and peripheral blood mononuclear cells.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
various concentrations of BSE
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Notably, it reduced the expression of PD-1, TIGIT, and LAG-3 immune checkpoint proteins in peripheral blood mononuclear cells, which are critical for antitumor immune response. These findings suggest that BSE has promising anticancer and immunomodulatory properties that warrant further investigation in preclinical models.
Blueberry stem extract (BSE), which contains phenolic compounds like proanthocyanidins, reduces liver lipid synthesis, boosts anti-adult T-cell leukemia action, protects retinal cells from blue light
APA
Moghtaderi H, Darweesh M, et al. (2026). Dual anticancer and immunoregulatory actions of blueberry stem extract in breast cancer cells and peripheral blood mononuclear cells.. Bioscience, biotechnology, and biochemistry, 90(2), 243-251. https://doi.org/10.1093/bbb/zbaf182
MLA
Moghtaderi H, et al.. "Dual anticancer and immunoregulatory actions of blueberry stem extract in breast cancer cells and peripheral blood mononuclear cells.." Bioscience, biotechnology, and biochemistry, vol. 90, no. 2, 2026, pp. 243-251.
PMID
41348970 ↗
Abstract 한글 요약
Blueberry stem extract (BSE), which contains phenolic compounds like proanthocyanidins, reduces liver lipid synthesis, boosts anti-adult T-cell leukemia action, protects retinal cells from blue light damage, and prevents lacrimal hyposecretion. However, the anticancer functions and immunomodulatory effects of BSE are not well understood. To assess the anticancer properties of BSE, MCF-7 and MDA-MB-231 breast cancer (BC) cells were treated with various concentrations of BSE. BSE suppressed the growth of BC cells in a manner dependent on both dose and exposure times. Furthermore, it triggered apoptosis by disrupting mitochondrial membrane potential. BSE also inhibited cell motility in BC cells. Notably, it reduced the expression of PD-1, TIGIT, and LAG-3 immune checkpoint proteins in peripheral blood mononuclear cells, which are critical for antitumor immune response. These findings suggest that BSE has promising anticancer and immunomodulatory properties that warrant further investigation in preclinical models.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Blueberry Plants
- Breast Neoplasms
- Leukocytes
- Mononuclear
- Plant Extracts
- Apoptosis
- Female
- Plant Stems
- Cell Movement
- Membrane Potential
- Mitochondrial
- Antineoplastic Agents
- Phytogenic
- Cell Proliferation
- Cell Line
- Tumor
- MCF-7 Cells
- apoptosis
- blueberry stem
- breast cancer
- immune checkpoint protein
- mitochondrial membrane potential
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