Synergistic Anticancer Effects of Apatinib and PD-L1 Inhibition in Breast Cancer.
1/5 보강
Studies in breast cancer have demonstrated that apatinib exhibits both antiangiogenic and antitumor effects, while PD-L1 inhibitors have similarly shown meaningful clinical benefit.
APA
Han D, Xu J, Guo C (2026). Synergistic Anticancer Effects of Apatinib and PD-L1 Inhibition in Breast Cancer.. Journal of mammary gland biology and neoplasia, 31(1). https://doi.org/10.1007/s10911-026-09600-3
MLA
Han D, et al.. "Synergistic Anticancer Effects of Apatinib and PD-L1 Inhibition in Breast Cancer.." Journal of mammary gland biology and neoplasia, vol. 31, no. 1, 2026.
PMID
41619044
Abstract
Studies in breast cancer have demonstrated that apatinib exhibits both antiangiogenic and antitumor effects, while PD-L1 inhibitors have similarly shown meaningful clinical benefit. Building upon these observations, this study evaluated the potential synergistic antitumor effects of combining apatinib with a PD-L1 inhibitor and examined the mechanistic basis for their interaction in breast cancer. Notably, we found that this regimen could significantly suppress the proliferation, migration, and invasion of MCF-7 and MDA-MB-231 cells, and promote cell apoptosis. In addition, the levels of p-ERK, NF-κB, and Slug were markedly reduced in vitro. Collectively, these findings support the potential clinical utility of combining apatinib and PD-L1 inhibition, as evidenced by consistent in vitro and in vivo synergy.
MeSH Terms
Humans; Female; Pyridines; Breast Neoplasms; Drug Synergism; Cell Proliferation; Animals; Apoptosis; Cell Movement; B7-H1 Antigen; Xenograft Model Antitumor Assays; Mice; Cell Line, Tumor; MCF-7 Cells; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols
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