Linarin inhibits survival and metastasis in triple-negative breast cancer cell line MDA-MB-231 by downregulating NF-κB p-p65/MMP-9, upregulating Bax, and enhancing Caspase 3/7 expression.
1/5 보강
Triple Negative Breast Cancer (TNBC) is an aggressive type of breast cancer that is responsible for most of the cancer related deaths in women.
APA
Acar TY, Bulbul MV, et al. (2026). Linarin inhibits survival and metastasis in triple-negative breast cancer cell line MDA-MB-231 by downregulating NF-κB p-p65/MMP-9, upregulating Bax, and enhancing Caspase 3/7 expression.. Natural product research, 40(4), 1085-1094. https://doi.org/10.1080/14786419.2025.2507160
MLA
Acar TY, et al.. "Linarin inhibits survival and metastasis in triple-negative breast cancer cell line MDA-MB-231 by downregulating NF-κB p-p65/MMP-9, upregulating Bax, and enhancing Caspase 3/7 expression.." Natural product research, vol. 40, no. 4, 2026, pp. 1085-1094.
PMID
40433756 ↗
Abstract 한글 요약
Triple Negative Breast Cancer (TNBC) is an aggressive type of breast cancer that is responsible for most of the cancer related deaths in women. Traditional two-dimensional (2D) cell cultures are insufficient to mimic the complex tumour environment, so three-dimensional (3D) spheroid cultures are used to provide a more accurate model. Our study explores the anticancer and antimetastatic effects of linarin on TNBC cell line MDA-MB-231 cells. We conducted experiments using both 2D and 3D cultured cells. Linarin treatment reduced cell viability (2D IC:120.8 µM *** < 0.001, 3D IC: 1949 µM **** < 0.0001 respectively) and migration (*** < 0.001, **** < 0.0001), increased apoptosis, and upregulated Bax and Caspase3/7 protein levels (**** < 0.0001). It also reduced p-p65 and MMP-9 protein expression levels (**** < 0.0001), suggesting possible suppression of survival and metastatic pathways. Linarin also led to a loss of spheroid compactness suggesting interference with its cancer-promoting activities. These findings suggest that linarin could be a promising therapeutic option for TNBC.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Triple Negative Breast Neoplasms
- Cell Line
- Tumor
- Cell Survival
- Female
- Matrix Metalloproteinase 9
- Apoptosis
- Caspase 3
- bcl-2-Associated X Protein
- Caspase 7
- Down-Regulation
- Transcription Factor RelA
- Up-Regulation
- Cell Movement
- NF-kappa B
- 3D cell culture
- TNBC
- apoptosis
- linarin
- metastasis
- natural product
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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