KLAK peptide in anticancer therapy: Achieving cancer cell apoptosis via mitochondrial membrane disruption using homing domains introduction and other modifications.
1/5 보강
An amphiphilic α-helical peptide called KLAK (sequence KLAKLAKKLAKLAK) possesses antimicrobial and anticancer activity.
APA
Kotalík K, Etrych T (2026). KLAK peptide in anticancer therapy: Achieving cancer cell apoptosis via mitochondrial membrane disruption using homing domains introduction and other modifications.. European journal of medicinal chemistry, 302(Pt 2), 118339. https://doi.org/10.1016/j.ejmech.2025.118339
MLA
Kotalík K, et al.. "KLAK peptide in anticancer therapy: Achieving cancer cell apoptosis via mitochondrial membrane disruption using homing domains introduction and other modifications.." European journal of medicinal chemistry, vol. 302, no. Pt 2, 2026, pp. 118339.
PMID
41197473 ↗
Abstract 한글 요약
An amphiphilic α-helical peptide called KLAK (sequence KLAKLAKKLAKLAK) possesses antimicrobial and anticancer activity. KLAK peptide disrupts bacterial membrane as well as eukaryotic mitochondrial membrane, which makes it an interesting tool for killing cancer cells. Nevertheless, the peptide itself suffers from inappropriate distribution in the body, low cell internalization ability causing its insufficient anticancer efficacy and potential toxicity toward the healthy part of the organism. This review focuses on the strategies, which have been widely employed to overcome this obstacle and reach mitochondria destruction and thus enhance anticancer effect in vitro and in vivo in various types of tumors. Various approaches to targeting KLAK towards cancer cells are discussed, such as peptide-based homing domains or amino acid modifications.
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