Inhibitory glutamatergic feedback for brain tumor therapy.
1/5 보강
Neuronal excitatory activity promotes glioma progression through glutamate-mediated signaling, yet effective ways to counter this using intrinsic brain mechanisms remain undefined.
APA
Lee RX (2026). Inhibitory glutamatergic feedback for brain tumor therapy.. Medical oncology (Northwood, London, England), 43(2), 121. https://doi.org/10.1007/s12032-025-03212-3
MLA
Lee RX. "Inhibitory glutamatergic feedback for brain tumor therapy.." Medical oncology (Northwood, London, England), vol. 43, no. 2, 2026, pp. 121.
PMID
41557050 ↗
Abstract 한글 요약
Neuronal excitatory activity promotes glioma progression through glutamate-mediated signaling, yet effective ways to counter this using intrinsic brain mechanisms remain undefined. Repeated low-frequency neuronal stimulation can lead to glutamate buildup and pathway-specific activation of inhibitory presynaptic metabotropic glutamate receptors (mGluRs) within neural circuits. This perspective introduces a hypothesis that this mechanism can disrupt tumor-promoting neuron-glioma interactions. This direction introduces a biologically grounded strategy for a distinctive therapeutic path in precision neuro-oncology.
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