Durvalumab-associated membranous nephropathy: a case report and brief literature review.
증례보고
1/5 보강
Immune checkpoint inhibitors can trigger renal immune-related adverse events, including glomerular disease.
APA
Mizoguchi R, Tashiro T, Sakakima M (2026). Durvalumab-associated membranous nephropathy: a case report and brief literature review.. CEN case reports, 15(1), 30. https://doi.org/10.1007/s13730-025-01038-6
MLA
Mizoguchi R, et al.. "Durvalumab-associated membranous nephropathy: a case report and brief literature review.." CEN case reports, vol. 15, no. 1, 2026, pp. 30.
PMID
41569470 ↗
Abstract 한글 요약
Immune checkpoint inhibitors can trigger renal immune-related adverse events, including glomerular disease. We report an 84-year-old man with non-small cell lung cancer who developed nephrotic syndrome after starting durvalumab. Proteinuria rose to 4+ four weeks into durvalumab therapy, and by week 6 serum albumin had fallen to 2.7 g/dL, prompting discontinuation. He was referred in January 2024 with serum albumin 2.0 g/dL and a urine protein-creatinine ratio of 13.57 g/gCr. Kidney biopsy demonstrated membranous nephropathy: capillary-wall thickening with spike formation on PAM, granular capillary-wall IgG on immunofluorescence, and scattered subepithelial deposits with widespread foot-process effacement on electron microscopy. IgG subclass staining showed a non-IgG4-dominant pattern (IgG1 > IgG4 > IgG2 > IgG3), supporting secondary MN in the setting of ICI exposure. Prednisolone 0.7 mg/kg/day (50 mg/day) was initiated, inducing complete remission by day 13, with sustained remission during taper to 5 mg/day. To our knowledge, this is the first report of de novo MN temporally associated with durvalumab; together with the available literature on ICI-associated MN, these findings support prednisolone (glucocorticoids) as a reasonable first-line therapy.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Male
- Glomerulonephritis
- Membranous
- Aged
- 80 and over
- Antibodies
- Monoclonal
- Carcinoma
- Non-Small-Cell Lung
- Lung Neoplasms
- Prednisolone
- Nephrotic Syndrome
- Immune Checkpoint Inhibitors
- Biopsy
- Proteinuria
- Kidney
- Durvalumab
- Immune checkpoint inhibitor
- Kidney irAE
- Membranous nephropathy
- Nephrotic syndrome
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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