Cadmium interferes with the antiproliferative effect of fulvestrant in endocrine therapy-resistant estrogen receptor α-positive breast cancer cells.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: BC may experience disease progression despite FUL treatment, suggesting potential interactions between FUL and Cd in long-term estrogen-deprived (LTED) cells
I · Intervention 중재 / 시술
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C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
Western blotting showed that Cd pre/post-treatment did not affect FUL-induced ERα degradation. Hence, Cd could suppress the antiproliferative effect of FUL in LTED cells.
Fulvestrant (FUL), an estrogen receptor α (ERα)-degradative anti-estrogen, is used alone or in combination with cyclin-dependent kinase 4/6 inhibitors for the treatment of advanced ERα-positive breast
APA
Kanameda K, Hirao-Suzuki M, Takeda S (2026). Cadmium interferes with the antiproliferative effect of fulvestrant in endocrine therapy-resistant estrogen receptor α-positive breast cancer cells.. Toxicology letters, 416, 111829. https://doi.org/10.1016/j.toxlet.2026.111829
MLA
Kanameda K, et al.. "Cadmium interferes with the antiproliferative effect of fulvestrant in endocrine therapy-resistant estrogen receptor α-positive breast cancer cells.." Toxicology letters, vol. 416, 2026, pp. 111829.
PMID
41525851 ↗
Abstract 한글 요약
Fulvestrant (FUL), an estrogen receptor α (ERα)-degradative anti-estrogen, is used alone or in combination with cyclin-dependent kinase 4/6 inhibitors for the treatment of advanced ERα-positive breast cancer (BC) in postmenopausal women. Cadmium (Cd), an environmental pollutant and metalloestrogen, binds to ERα as a ligand. Patients with BC may experience disease progression despite FUL treatment, suggesting potential interactions between FUL and Cd in long-term estrogen-deprived (LTED) cells. Therefore, the effect of FUL and Cd interaction in LTED cells, a model of postmenopausal BC, was investigated. LTED cells were treated with FUL and Cd at therapeutically or physiologically relevant concentrations, both simultaneously and sequentially (either with FUL treatment followed by Cd or Cd pre-treatment followed by FUL). FUL treatment alone decreased LTED cell viability; however, Cd pre/post-treatment attenuated the antiproliferative effect of FUL. Western blotting showed that Cd pre/post-treatment did not affect FUL-induced ERα degradation. Hence, Cd could suppress the antiproliferative effect of FUL in LTED cells.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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