Newly Designed 3d-Metal(II) Complexes From Thiadiazole-Carboxamide Ligand With Potential Antimicrobial, Anticancer, and DNA-Reactivity.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
The current compounds, as inhibitors, show effective antiproliferative action on the targeted microorganisms and tumor growth.
I · Intervention 중재 / 시술
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C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
The influence of the metal ions in the complexing prodrugs enhanced their biochemical efficacy compared to HLtos. This study contributes to the rapidly developing field of metallo-prodrugs, which holds growing promise for cancer and infection therapy.
A thiadiazole-carboxamide derivative (HLtos) is complexed to three 3d-metals (Co(II), Cu(II), and Ni(II) ions) in equal amounts, affording three new complexes (CoLtosCl.2HO, CuLtosNO, and NiLtosNO), r
APA
Adam MSS, El-Hady OM, et al. (2026). Newly Designed 3d-Metal(II) Complexes From Thiadiazole-Carboxamide Ligand With Potential Antimicrobial, Anticancer, and DNA-Reactivity.. Journal of biochemical and molecular toxicology, 40(2), e70734. https://doi.org/10.1002/jbt.70734
MLA
Adam MSS, et al.. "Newly Designed 3d-Metal(II) Complexes From Thiadiazole-Carboxamide Ligand With Potential Antimicrobial, Anticancer, and DNA-Reactivity.." Journal of biochemical and molecular toxicology, vol. 40, no. 2, 2026, pp. e70734.
PMID
41674462 ↗
Abstract 한글 요약
A thiadiazole-carboxamide derivative (HLtos) is complexed to three 3d-metals (Co(II), Cu(II), and Ni(II) ions) in equal amounts, affording three new complexes (CoLtosCl.2HO, CuLtosNO, and NiLtosNO), respectively. The biological reactivity of the new compounds is demonstrated versus the growing development of human cancer cell lines and the microbial series, emphasizing the significant efficacy of the central metal influence in CoLtosCl.2HO, CuLtosNO, and NiLtosNO in comparison to HLtos. They are tested through their ability to interact with DNA (deoxyribonucleic acid) using spectrophotometric/viscometric methods. The current compounds, as inhibitors, show effective antiproliferative action on the targeted microorganisms and tumor growth. Incorporation of Cu and Co ions in the complex amplified the anti-migration activity in the breast cancer cell line. Gibbs free energy and binding constant are applied to elucidate the interaction modes of HLtos, CoLtosCl.2HO, CuLtosNO, and NiLtosNO with DNA. The influence of the metal ions in the complexing prodrugs enhanced their biochemical efficacy compared to HLtos. This study contributes to the rapidly developing field of metallo-prodrugs, which holds growing promise for cancer and infection therapy.
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