Diverse Biological Functions of IGF2BPs in Hepatobiliary Cancers and Their Clinical Relevance.
1/5 보강
Hepatobiliary malignancies remain a major clinical challenge because they are highly aggressive and resistant to therapy.
APA
Yin Z, Lang Q, et al. (2026). Diverse Biological Functions of IGF2BPs in Hepatobiliary Cancers and Their Clinical Relevance.. Frontiers in bioscience (Landmark edition), 31(2), 44550. https://doi.org/10.31083/FBL44550
MLA
Yin Z, et al.. "Diverse Biological Functions of IGF2BPs in Hepatobiliary Cancers and Their Clinical Relevance.." Frontiers in bioscience (Landmark edition), vol. 31, no. 2, 2026, pp. 44550.
PMID
41761983 ↗
Abstract 한글 요약
Hepatobiliary malignancies remain a major clinical challenge because they are highly aggressive and resistant to therapy. In eukaryotes, N6-methyladenosine (m6A), the most prevalent internal RNA modification, regulates post-transcriptional gene expression. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1/2/3) act as pivotal m6A readers, stabilizing coding and non-coding RNAs to modulate cancer-related signaling networks. In hepatobiliary cancers, dysregulated IGF2BP expression is associated with proliferation, metastasis, metabolic adaptation, and immune evasion, underscoring its potential as a biomarker and therapeutic targets. This review provides a comprehensive overview of IGF2BP-mediated regulatory mechanisms and explores their translational potential in precision diagnostics and targeted interventions.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- RNA-Binding Proteins
- Liver Neoplasms
- Gene Expression Regulation
- Neoplastic
- Biliary Tract Neoplasms
- Signal Transduction
- Adenosine
- Biomarkers
- Tumor
- Animals
- Clinical Relevance
- N6-methyladenosine
- gallbladder cancer
- hepatobiliary cancers
- hepatocellular carcinoma
- intrahepatic cholangiocarcinoma
- molecular mechanisms
- non-coding RNA
- targeted therapy
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