Recurrent Squamous Cell Carcinoma of the Head & Neck: Novel Approaches to Re-Irradiation.

Heron DE; Ward MC; Yom SS; Peterson CR; Spencer SA; Echevarria M

doi:10.1016/j.otc.2025.08.010

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Recurrent Squamous Cell Carcinoma of the Head & Neck: Novel Approaches to Re-Irradiation.

Otolaryngologic clinics of North America 2026 Vol.59(1) p. 199-210

Heron DE, Ward MC, Yom SS, Peterson CR, Spencer SA, Echevarria M

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Recurrent squamous cell carcinoma of the head and neck remains a formidable clinical challenge.

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APA Heron DE, Ward MC, et al. (2026). Recurrent Squamous Cell Carcinoma of the Head & Neck: Novel Approaches to Re-Irradiation.. Otolaryngologic clinics of North America, 59(1), 199-210. https://doi.org/10.1016/j.otc.2025.08.010

MLA Heron DE, et al.. "Recurrent Squamous Cell Carcinoma of the Head & Neck: Novel Approaches to Re-Irradiation.." Otolaryngologic clinics of North America, vol. 59, no. 1, 2026, pp. 199-210.

PMID 41027765

DOI 10.1016/j.otc.2025.08.010

Abstract

Recurrent squamous cell carcinoma of the head and neck remains a formidable clinical challenge. This article provides detailed current and novel reirradiation strategies, including integration of systemic, targeted, and immunotherapeutic approaches, including highlighting ongoing clinical trials.

MeSH Terms

Humans; Neoplasm Recurrence, Local; Re-Irradiation; Squamous Cell Carcinoma of Head and Neck; Head and Neck Neoplasms; Immunotherapy