Mechanisms of whole-genome doubling in cancer evolution.
1/5 보강
Whole-genome doubling (WGD) has recently emerged as one of the most common genomic alterations in cancer and is associated with genomic instability, drug resistance, and metastasis.
APA
McKenney CD, Regot S (2026). Mechanisms of whole-genome doubling in cancer evolution.. Trends in cancer, 12(2), 175-185. https://doi.org/10.1016/j.trecan.2025.10.001
MLA
McKenney CD, et al.. "Mechanisms of whole-genome doubling in cancer evolution.." Trends in cancer, vol. 12, no. 2, 2026, pp. 175-185.
PMID
41206259 ↗
Abstract 한글 요약
Whole-genome doubling (WGD) has recently emerged as one of the most common genomic alterations in cancer and is associated with genomic instability, drug resistance, and metastasis. However, WGD also generates unique vulnerabilities that create a therapeutic window between cancer cells and healthy cells. Over the past few years, there has been a rapid growth in our understanding of WGD at a molecular level. In this review, we discuss the causes and immediate cellular effects of, and therapeutic considerations for, WGD in cancer.
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