Current and Upcoming Trials in Localized Prostate Cancer.

The diagnosis and management of localized prostate cancer (PCa) remains an active field of research, with many recently published and upcoming clinical trials. Advances in local therapy, management of pelvic lymph nodes, imaging, systemic treatments, and quality of life have the potential to optimize outcomes while minimizing toxicity. This review synthesizes findings from recently completed phase III trials, highlights ongoing studies and provides an update on evidence-based management approaches and emerging innovations which may improve the care of patients with localized PCa.