Open Questions in Particle Therapy for Head and Neck Cancer.

Rieu R; Carnell D; Chua MLK; Lowe M; Mendes R; Thompson A

doi:10.1016/j.otc.2025.09.002

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Open Questions in Particle Therapy for Head and Neck Cancer.

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Otolaryngologic clinics of North America 2026 Vol.59(1) p. 167-179

Rieu R, Carnell D, Chua MLK, Lowe M, Mendes R, Thompson A

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APA Rieu R, Carnell D, et al. (2026). Open Questions in Particle Therapy for Head and Neck Cancer.. Otolaryngologic clinics of North America, 59(1), 167-179. https://doi.org/10.1016/j.otc.2025.09.002

MLA Rieu R, et al.. "Open Questions in Particle Therapy for Head and Neck Cancer.." Otolaryngologic clinics of North America, vol. 59, no. 1, 2026, pp. 167-179.

PMID 41271291

DOI 10.1016/j.otc.2025.09.002

Abstract

Particle therapy's distinct depth-dose profile may reduce normal-tissue dose while maintaining intensity-modulated radiotherapy-comparable target coverage, thereby potentially lowering treatment-related toxicity and/or enabling safe dose escalation. We consider uncertainties in adult head and neck particle therapy across delivery/verification, radiobiology, and patient selection.

MeSH Terms

Humans; Head and Neck Neoplasms; Radiotherapy, Intensity-Modulated; Radiotherapy Dosage; Proton Therapy; Radiotherapy Planning, Computer-Assisted; Patient Selection