Interplay between cancer cell lipotypes and disease states.
1/5 보강
While the initial transformation of cancer cells is driven by genetic alterations, tumor cell behaviors and functional states are dynamically regulated by cell-intrinsic factors including proteins, me
APA
Wang X, Zou Y (2026). Interplay between cancer cell lipotypes and disease states.. Trends in cancer, 12(2), 147-158. https://doi.org/10.1016/j.trecan.2025.10.009
MLA
Wang X, et al.. "Interplay between cancer cell lipotypes and disease states.." Trends in cancer, vol. 12, no. 2, 2026, pp. 147-158.
PMID
41298166 ↗
Abstract 한글 요약
While the initial transformation of cancer cells is driven by genetic alterations, tumor cell behaviors and functional states are dynamically regulated by cell-intrinsic factors including proteins, metabolites and lipids, and extrinsic microenvironmental factors. Emerging multi-omics technologies highlighted that cancer cells exhibit distinct lipidome compositions and employ specific lipid metabolic circuits for chemical conversions - collectively defined as 'lipotypes'. We review the interplay between cancer lipotypes and cellular states, focusing on interpreting how being at different positions along the spectra of representative lipid metabolic axes influences cancerous traits. We aim to instill a system biology perspective to integrate 'lipotypes' into the established 'genotype-phenotype' framework in cancer.
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