Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics.
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Renal cell carcinoma (RCC) outcomes are shaped by a complex tumor microenvironment (TME), where malignant cells represent only a minority of the tissue.
APA
Gok Yavuz B, Khanmammadova N, et al. (2026). Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics.. Trends in cancer, 12(2), 186-207. https://doi.org/10.1016/j.trecan.2025.11.001
MLA
Gok Yavuz B, et al.. "Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics.." Trends in cancer, vol. 12, no. 2, 2026, pp. 186-207.
PMID
41339185 ↗
Abstract 한글 요약
Renal cell carcinoma (RCC) outcomes are shaped by a complex tumor microenvironment (TME), where malignant cells represent only a minority of the tissue. Recent advances in single-cell technologies - including single-cell RNA sequencing, single-nucleus RNA sequencing, single-cell assay for transposase-accessible chromatin sequencing, single-cell T-cell receptor sequencing, and imaging mass cytometry - have uncovered the cellular, regulatory, and spatial heterogeneity of RCC. Here, we synthesize insights from these approaches to define diverse CD8 T-cell subsets and exhaustion trajectories, as well as the origins, phenotypic diversity, and functional states of other immune cells including tumor-associated macrophages, dendritic cells, natural killer cells and cancer-associated fibroblasts. Together, these findings highlight the transformative potential of single-cell technologies to unravel TME complexity, identify biomarkers of therapeutic response, and guide precision immunotherapy in RCC.
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